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描述 概述 Full-length, recombinant, human phosphodiesterdase 7A1 (PDE7A1) expressed in S. frugiperda insect cells using a baculovirus expression system. PDE7A1 is required for T-cell activation induced by the costimulation of CD3 and CD28 receptors. Increased PDE7A1 correlates with a decrease in cAMP, increased IL-2, and increased cell proliferation. Supplied as a partially purified preparation of catalytically active enzyme useful for inhibitor and activator assays. 产品目录编号 524751 品牌系列 Calbiochem®
同义词 hPDE7A1 应用数据 
Increasing concentrations of SB36207, a PDE7A1 inhibitor, were mixed with the enzyme and the activity was measured.参考 参考 Han, P., et al. 2006. J. Biol. Chem. 281, 15050.
Lugnier, C. 2006. Pharmacol Ther. 109, 366.
Bloom, T.J., and Beavo, J.A. 1996. Proc. Natl. Acad. Sci. U S A 93, 14188.产品信息 活性 ≥ 0.5 U/µl 形式 Liquid 配方 In 150 mM NaCl, 10 mM Tris, 0.1% NP-40, pH 8.3. 储存和货运信息 货运代码 Dry Ice Only
毒性 Standard Handling
储存 ≤ -70°C
避免冻结 / 解冻 Avoid freeze/thaw
无需冷冻 No
特殊指南 Following initial thaw, aliquot and freeze (-70°C).
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