merck millipore,默克密理愽
  • merck millipore,默克密理博,MABN679,Anti-BHMT Antibody, clone 8C11H5

  • merck millipore,默克密理博,MABN679,Anti-BHMT Antibody, clone 8C11H5

    产品名称：Anti-BHMT Antibody, clone 8C11H5
    产品型号：MABN679
    Anti-BHMT Antibody, clone 8C11H5 is a highly specific mouse monoclonal antibody, that targets Betaine--homocysteine S-methyltransferase 1 & has been tested in IHC & western blotting.

    merck millipore,默克密理博,MABN679,Anti-BHMT Antibody, clone 8C11H5

  • 产品介绍
  • merck millipore,默克密理博,MABN679,Anti-BHMT Antibody, clone 8C11H5

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWB, IHCMAscitesMonoclonal Antibody
    描述
    产品目录编号 MABN679
    Replaces MABE536
    描述 Anti-BHMT Antibody, clone 8C11H5
    Alternate Names
    • Betaine--homocysteine S-methyltransferase 1
    背景信息 Betaine, (trimethylglycine) is an organic osmolyte that is available for cells by either choline oxidase-catalyzed synthesis or concentrative uptake by the betaine/GABA transport system (BGT-1). The intracellular accumulation of betaine protects cells from different kinds of stress including long-lasting dehydration, ischemia-reperfusion, and heat shock. Betaine has been considered a “chemical chaperone” because it prevents protein denaturation under adverse conditions, a property that likely contributes to the cytoprotective effects of this osmolyte.
    Betaine--homocysteine S-methyltransferase 1, or betaine-homocysteine methyltransferase (BHMT) is the enzyme that is responsible for the metabolic elimination of betaine and homocysteine via their conversion to dimethylglycine and methionine. As such BHMT is one of a handful of key enzymes keenly responsible for betaine levels. BHMT is expressed at high levels in the human liver and kidney, localizing in the ER and cytoplasmic regions. BHMT expression is largely regulated at the level of the gene. BHMT activity becomes essential when folate-dependent remethylation is impaired because of nutritional deficiencies as it then provides the source for methionine. Deficiencies in BHMT can lead a variety of disorders ranging from vascular disease to neural tube birth defects such as spina bifida, fatty liver disease and cirrhosis all which can be linked to betaine metabolism disorders. EMD-Millipore’s Anti-BHMT mouse monoclonal antibody, clone 635, has been tested in western blots using recombinantly expressed BHMT cDNA and by immunohistochemistry on paraffin embedded human liver tissue samples.
    产品信息
    格式 Ascites
    控制
    • HepG2 cell lysate
    演示 Mouse monoclonal IgG2b ascitic fluid containing up to 0.1% sodium azide.
    应用
    应用 Anti-BHMT Antibody, clone 8C11H5 is a highly specific mouse monoclonal antibody, that targets Betaine--homocysteine S-methyltransferase 1 & has been tested in IHC & western blotting.
    主要应用
    • Western Blotting
    • Immunohistochemistry
    应用说明 Immunohistochemistry Analysis: 1:500-1,000 dilution from a representative lot detected BHMT in human kidney and liver tissues.
    生物信息
    免疫原品种 Purified recombinant fragment of BHMT expressed in E. coli.
    克隆 8C11H5
    宿主 Mouse
    同种型 IgG1
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_001704
    基因符号
    • BHMT
    纯化方法 Unpurified
    UniProt编号
    • Q93088
    产品使用声明
    质量保证 Evaluated by Western Blotting in HepG2 cell lysate.

    Western Blotting Analysis: A 1:500 dilution of this antibody detected BHMT in 10 µg of HepG2 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at -20°C from date of receipt.
    Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,MABN679,Anti-BHMT Antibody, clone 8C11H5

上一件merck millipore产品：merck millipore,默克密理博,561300,E-Selectin, Human, Recombinant, CHO Cells
下一件merck millipore产品：merck millipore,默克密理博,12-429,GST-Axin


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