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描述 概述 Recombinant, human SIRT1 histone deacetylase consisting of amino acids 193-741 fused at the N-terminus to GST and expressed in E. coli. SIRT1 preferentially deacetylates histones H4 at K16 and H3 at K9 and interacts with and deacetylates histone H1 at K26. More than a dozen non-histone proteins have been found to serve as substrates for SIRT1. It plays a role in several biological processes including stress resistance, metabolism, differentiation, and aging. The active deacetylase is useful in the study of SIRT1 regulation and for inhibitor screening. 产品目录编号 524743 品牌系列 Calbiochem®
同义词 Silent mating type information regulation 2 homolog, Sirtuin1, GST-Fusion, Human, Recombinant, E. coli 参考 参考 Kolthur-Seetharam, U., et al. 2006. Cell Cycle 5, 873.
Solomon, J.M., et al. 2006. Mol. Cell. Biol. 26, 28.产品信息 形式 Liquid 配方 In 100 mM NaCl, 25 mM Tris-HCl, 0.05% Tween®-20 detergent, 20% glycerol, pH 8.0. Molar Mass 82000 生物信息 纯度 ≥80% by SDS-PAGE 特异活性 ≥8 units/µg protein 浓缩标签 Please refer to vial label for lot-specific concentration
储存和货运信息 货运代码 Dry Ice Only
毒性 Standard Handling
储存 ≤ -70°C
避免冻结 / 解冻 Avoid freeze/thaw
无需冷冻 No
特殊指南 Following initial thaw, aliquot and freeze (-70°C).
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