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merck millipore,默克密理博,04-593,Anti-JAM1 (NT) Antibody, rabbit monoclonal, clone EP1042Y
产品名称：Anti-JAM1 (NT) Antibody, rabbit monoclonal, clone EP1042Y
产品型号：04-593
Anti-JAM1 (N-Term) Antibody, Rabbit, clone EP1042Y detects level of JAM1 (N-Term) & has been published & validated for use in WB, IH(P).
merck millipore,默克密理博,04-593,Anti-JAM1 (NT) Antibody, rabbit monoclonal, clone EP1042Y
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, H, M WB Rb Purified Monoclonal Antibody 描述 产品目录编号 04-593 品牌系列 Upstate
商名 - Upstate
描述 Anti-JAM1 (NT) Antibody, rabbit monoclonal, clone EP1042Y Alternate Names - Junctional Adhesion Molecule-1
背景信息 Junctional Adhesion Molecules (JAMs) are components and regulators of the well-characterized epithelial and endothelial tight junction. JAM is selectively concentrated at intercellular junctions of endothelial and epithelial cells of different origins. Microscopy shows that JAM codistributes with tight junction components at the apical region of the intercellular cleft. A mAb directed to JAM (BV11) was found to inhibit spontaneous and chemokine-induced monocyte transmigration through an endothelial cell monolayer in vitro. Systemic treatment of mice with BV11 mAb blocked monocyte infiltration upon chemokine administration in subcutaneous air pouches (1). The human protein shares a highly conserved structure and sequence with the murine protein. However it is distinct in that it is constitutively expressed on circulating neutrophils, monocytes, platelets and lymphocyte subsets (2). 产品信息 格式 Purified 演示 Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. 应用 应用 Anti-JAM1 (N-Term) Antibody, Rabbit, clone EP1042Y detects level of JAM1 (N-Term) & has been published & validated for use in WB, IH(P). 主要应用 - Western Blotting
应用说明 WB: 1:2000
IHC: 1:100 - 250 (Paraffin-embedded human liver)生物信息 免疫原品种 A synthetic peptide corresponding to residues near the N-terminus of human JAM1. 克隆 EP1042Y 宿主 Rabbit 特异性 Recognizes Human, Mouse, Rat JAM1 (N-Term). 品种反应性 RatHumanMouse Species Reactivity Note Human, Mouse, Rat (positive control: Hela cell lysate) 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_144503.1
- NM_144502.1
- NM_144504.1
- NM_016946.3
Entrez基因汇总 Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established. 基因符号 - KAT
- F11R
- JAM-A
- PAM-1
- JAMA
- CD321
- JAM
- JAM1
- JAM-1
- JCAM
纯化方法 Protein A purfied UniProt编号 - Q9Y624
UniProt汇总 FUNCTION: SwissProt: Q9Y624 # Seems to plays a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation.
SIZE: 299 amino acids; 32583 Da
SUBUNIT: Interacts with the first PDZ domain of PARD3. The association between PARD3 and PARD6B probably disrupts this interaction (By similarity). Interacts with the ninth PDZ domain of MPDZ.
SUBCELLULAR LOCATION: Cell junction, tight junction; Single-pass type I membrane protein. Note=Localized at tight junctions of both epithelial and endothelial cells.
PTM: N-glycosylated.
SIMILARITY: SwissProt: Q9Y624 ## Belongs to the immunoglobulin superfamily. & Contains 2 Ig-like V-type (immunoglobulin-like) domains.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Store at -20 °C. Stable for 12 months from date of receipt. 包装信息 数量 100 µL
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