merck millipore,默克密理愽
  • merck millipore,默克密理博,521235,PDGFR Tyrosine Kinase Inhibitor VI, SU6668 - CAS 210644-62-5 - Calbiochem

  • merck millipore,默克密理博,521235,PDGFR Tyrosine Kinase Inhibitor VI, SU6668 - CAS 210644-62-5 - Calbiochem

    产品名称：PDGFR Tyrosine Kinase Inhibitor VI, SU6668 - CAS 210644-62-5 - Calbiochem
    产品型号：521235
    The PDGFR Tyrosine Kinase Inhibitor VI, SU6668, also referenced under CAS 210644-62-5, controls the biological activity of PDGFR Tyrosine Kinase. This small molecule/inhibitor is primarily used for Ph More>>

    merck millipore,默克密理博,521235,PDGFR Tyrosine Kinase Inhibitor VI, SU6668 - CAS 210644-62-5 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,521235,PDGFR Tyrosine Kinase Inhibitor VI, SU6668 - CAS 210644-62-5 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₈H₁₈N₂O₃210644-62-5
    描述
    概述 A cell-permeable indolinone compound that acts as a potent ATP-competitive inhibitor against RTKs (receptor tyrosine kinases) Kit, PDGFRβ, VEGFR2 (Flk-1/KDR), FGFR1 activity in vitro (IC50 = 0.01, 0.1, 3.9, and 3.8 µM, respectively) and PDGF/VEGF/bFGF-mediated angiogenesis and tumor development in vivo. Although initially characterized as an RTK inhibitor, SU6668 is now also known to target ser/thr kinases Aurora A, Aurora B, TBK1 (NAK/T2K), and AMPK (IC50 = 0.85, 0.047, 1.4, and 1.8 µM, respectively), as well as non-receptor TKs Lyn and Yes (IC50 = 4.3 and 5.8 µM, respectively).
    产品目录编号 521235
    品牌系列 Calbiochem®
    同义词 (Z)-3-(2,4-Dimethyl-5-(2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-1H-pyrrol-3-yl)-propionic acid, VEGFR Tyrosine Kinase Inhibitor XXVII, VEGFR2 Kinase Inhibitor XXV, mTOR Inhibitor X, Aurora Kinase Inhibitor IV
    参考
    参考 Godl, K., et al. 2005. Cancer Res. 65, 6919.
    Laird, A.D., et al. 2002. FASEB J. 16, 681.
    Krystal, G.W., et al. 2001. Cancer Res. 61, 3660.
    Smolich, B.D., et al. 2001. Blood 97, 1413.
    Laird, A.D., et al. 2000. Cancer Res. 60, 4152.
    Shaheen, R.M., et al. 1999. Cancer Res. 59, 5412.
    Sun, L. et al. 1999. J. Med. Chem. 42, 5120.
    产品信息
    CAS号 210644-62-5
    形式 Dark yellow solid
    Hill配方 C₁₈H₁₈N₂O₃
    化学配方 C₁₈H₁₈N₂O₃
    Molar Mass 310.4
    结构配方图像
    生物信息
    纯度 ≥97% by HPLC
    理化信息
    溶解度 DMSO
    安全信息
    R相 R: 22-36/37/38

    Harmful if swallowed.
    Irritating to eyes, respiratory system and skin.
    S相 S: 26-36-45

    In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
    Wear suitable protective clothing.
    In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Harmful
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,521235,PDGFR Tyrosine Kinase Inhibitor VI, SU6668 - CAS 210644-62-5 - Calbiochem

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