merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB2638,Anti-Integrin beta7 Antibody, clone TN114

  • merck millipore,默克密理博,MAB2638,Anti-Integrin beta7 Antibody, clone TN114

    产品名称：Anti-Integrin beta7 Antibody, clone TN114
    产品型号：MAB2638
    Anti-Integrin beta7 Antibody, clone TN114 is an antibody against Integrin beta7 for use in FC, IP, IH.

    merck millipore,默克密理博,MAB2638,Anti-Integrin beta7 Antibody, clone TN114

  • 产品介绍
  • merck millipore,默克密理博,MAB2638,Anti-Integrin beta7 Antibody, clone TN114

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HIHC, FCAHmPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB2638
    描述 Anti-Integrin beta7 Antibody, clone TN114
    Alternate Names
    • Gut homing receptor beta subunit
    • integrin, beta 7
    • integrin beta 7 subunit
    背景信息 Integrin beta7 is an adhesion molecule belonging to the integrin beta chain family. It forms heterodimers with the alpha subunit, most notably the integrin alpha4 and alphaE subunits, functioning to mediate migration and homing of lymphocytes to the gut-associated lymphoid tissue (GALT). The heterodimer formed with alpha4, α4β7, is specifically involved in the homing and migration of lymphocytes to the gut, while αEβ7 is involved in the binding of T lymphocytes to epithelial cells and is induced by TGFβ1. Integrin beta7 has been observed in several different leukocyte lines.
    产品信息
    格式 Purified
    控制
    • Human peripheral blood mononuclear cells (PBMC's).
    演示 Purified armenian hamster monoclonal IgG in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Anti-Integrin beta7 Antibody, clone TN114 is an antibody against Integrin beta7 for use in FC, IP, IH.
    主要应用
    • Immunohistochemistry
    • Flow Cytometry
    生物信息
    免疫原品种 Purified human integrin beta7 protein.
    表位 Unknown
    克隆 TN114
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Armenian Hamster
    特异性 The antibody recognizes Integrin beta7.
    同种型 IgG
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with human.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_000880.1
    基因符号
    • ITGB7
    纯化方法 Protein G purfied
    UniProt编号
    • P26010
    UniProt汇总 FUNCTION: Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin.

    SUBUNIT STRUCTURE: Heterodimer of an alpha and a beta subunit. Beta-7 associates with either alpha-4 or alpha-E. Integrin alpha-4/beta-7 interacts with MADCAM1, VCAM, fibronectin, and may also interact with HIV-1 gp120.

    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

    TISSUE SPECIFICITY: Expressed in a variety of leukocyte lines.

    INDUCTION: Integrin alpha-E/beta-7 is induced by TGFB1.

    DOMAIN: Domain I contains three cation-binding sites: the ligand-integrin-binding site (LIMBS), the metal ion-dependent adhesion site (MIDAS), and the adjacent to MIDAS site (ADMIDAS). In the absence of a ligand or in calcium-dependent binding, only ADMIDAS is occupied. In magnesium-dependent binding all three sites bind metal ions. LIMBS positively modify ligand binding whereas ADMIDAS negatively modify ligand binding.

    SEQUENCE SIMILARITIES: Belongs to the integrin beta chain family.

    Contains 1 VWFA domain.
    产品使用声明
    质量保证 Evaluated by Flow Cytometry in human PBMC's.

    Flow Cytometry Analysis: 1 µg/mL of this antibody detected Integrin beta7 on human PBMC's.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB2638,Anti-Integrin beta7 Antibody, clone TN114

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