merck millipore,默克密理愽
  • merck millipore,默克密理博,517301,P-Glycoprotein Inhibitor, C-4 - Calbiochem

  • merck millipore,默克密理博,517301,P-Glycoprotein Inhibitor, C-4 - Calbiochem

    产品名称：P-Glycoprotein Inhibitor, C-4 - Calbiochem
    产品型号：517301
    The P-Glycoprotein Inhibitor, C-4 controls the biological activity of P-Glycoprotein. This small molecule/inhibitor is primarily used for Cancer applications.

    merck millipore,默克密理博,517301,P-Glycoprotein Inhibitor, C-4 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,517301,P-Glycoprotein Inhibitor, C-4 - Calbiochem

    重要规格表

    经验配方
    C₂₃H₁₈ClNO₄
    描述
    概述 A cell-permeable cinnamoyl compound that reversibly inhibits P-gp (P-glycoprotein) efflux function and reverses the MDR (multidrug resistance) phenotype with no noticeable effect on P-gp expression. Shown to significantly enhance Paclitaxel- (Cat. No. 580555) and Vincristine- (Cat. No. 677181) induced cytotoxicity as well as apoptosis in P-gp expressing KBV20C cells.
    产品目录编号 517301
    品牌系列 Calbiochem®
    同义词 (E)-4-Chloro-N-(3-(3-(4-hydroxy-3-methoxyphenyl)acryloyl)phenyl)benzamide, C-4
    参考
    参考 Kim, Y.K., et al. 2007. Biochem. Biophys. Res. Commun. 355, 136.
    Woo, H.B., et al. 2005. Bioorg. Med. Chem. Lett. 15, 3782.
    产品信息
    具有ATP竞争性 N
    形式 Yellow solid
    Hill配方 C₂₃H₁₈ClNO₄
    化学配方 C₂₃H₁₈ClNO₄
    Molar Mass 407.9
    可逆 Y
    结构配方图像
    生物信息
    主靶 P-Glycoprotein
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,517301,P-Glycoprotein Inhibitor, C-4 - Calbiochem

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