merck millipore,默克密理愽
  • merck millipore,默克密理博,420145,JAK3 Inhibitor VII, AD412 - CAS 796041-65-1 - Calbiochem

  • merck millipore,默克密理博,420145,JAK3 Inhibitor VII, AD412 - CAS 796041-65-1 - Calbiochem

    产品名称：JAK3 Inhibitor VII, AD412 - CAS 796041-65-1 - Calbiochem
    产品型号：420145
    The JAK3 Inhibitor VII, AD412, also referenced under CAS 796041-65-1, controls the biological activity of JAK3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation  More>>

    merck millipore,默克密理博,420145,JAK3 Inhibitor VII, AD412 - CAS 796041-65-1 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,420145,JAK3 Inhibitor VII, AD412 - CAS 796041-65-1 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₃H₂₀ClN₃O796041-65-1
    描述
    概述 A cell-permeable indole-3-propanamide immunosuppressant that is shown to selectively inhibit the kinase activity of JAK3 (by 81% and 36% at 90 and 30 µM, respectively) over that of JAK2 (by 29% and 0% at 90 and 30 µM, respectively) and reduce JAK1/3-dependent phosphorylations of Akt, STAT5a/b, and Erk1/2 in IL-2-stimulated CTL-L2 cells, but not JAK1/2-dependent STAT1 phosphorylation in INF-γ-stimulated U266 cultures. Reported to inhibit ConA-stimulated murine splenocytes and PHA-stimulated human PBL proliferation (IC50 = 17 and 25 µM, respectively) in vitro and be efficacious in ameliorating delayed hypersensitivity reaction in mice (by ~78% with a daily oral dose of 50 mg/kg) and in prolonging the survival of heart transplant-recipient rats (by >3-fold with 60 mg/kg/day, p.o.) in vivo.
    产品目录编号 420145
    品牌系列 Calbiochem®
    同义词 N-(Pyridin-4-yl)-3-[1-(4-chlorobenzyl)indol-3-yl]-propanamide
    参考
    参考 Carbonnelle, D., et al. 2009. J. Pharm. Exp. Ther. 331, 710.
    Carbonnelle, D., et al. 2007. Eur. J. Med. Chem. 42, 686.
    产品信息
    CAS号 796041-65-1
    形式 White solid
    Hill配方 C₂₃H₂₀ClN₃O
    化学配方 C₂₃H₂₀ClN₃O
    Molar Mass 389.9
    生物信息
    纯度 ≥95% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,420145,JAK3 Inhibitor VII, AD412 - CAS 796041-65-1 - Calbiochem

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