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  • merck millipore,默克密理博,ABE286,Anti-acetyl-p53 (Lys120) Antibody

  • merck millipore,默克密理博,ABE286,Anti-acetyl-p53 (Lys120) Antibody

    产品名称：Anti-acetyl-p53 (Lys120) Antibody
    产品型号：ABE286
    Anti-acetyl-p53 (Lys120) Antibody is a highly specific rabbit polyclonal antibody, that targets p53 & has been tested in Dot Blot & IP.

    merck millipore,默克密理博,ABE286,Anti-acetyl-p53 (Lys120) Antibody

  • 产品介绍
  • merck millipore,默克密理博,ABE286,Anti-acetyl-p53 (Lys120) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HIP, DBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 ABE286
    描述 Anti-acetyl-p53 (Lys120) Antibody
    Alternate Names
    • Tumor suppressor p53
    • Cellular tumor antigen p53
    • Antigen NY-CO-13
    • Phosphoprotein p53
    背景信息 p53 is a DNA-binding, oligomerization domain and transcription activation domain-containing tumor suppressor that upregulates growth arrest and apoptosis-related genes in response to stress signals, thereby influencing programmed cell death, cell differentiation and cell cycle control mechanisms. p53 localizes to the nucleus yet can be chaperoned to the cytoplasm by the negative regulator MDM2, an E3 ubiquitin ligase that is upregulated in the presence of active p53, where MDM2 polyubiquitinates p53 for proteasome targeting. p53 can assemble into tetramers in the absence of DNA, fluctuates between latent and active (DNA-binding) conformations, and is differentially activated through posttranslational modifications including phosphorylation and acetylation. Mutations in the DNA-binding domain (DBD) (amino acids 110-286) of p53 can compromise energetically favorable association with cis elements and are implicated in several human cancers.
    产品信息
    格式 Affinity Purified
    控制
    • Non-acetylated and acetylated p53 peptides
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Anti-acetyl-p53 (Lys120) Antibody is a highly specific rabbit polyclonal antibody, that targets p53 & has been tested in Dot Blot & IP.
    主要应用
    • Immunoprecipitation
    • Dot Blot
    应用说明 Immunoprecipitation Analysis: 1 µg from a representative lot immunoprecipitated acetyl-p53 in camptothecin treated HCT116 cell lysate.

    Immunoprecipitation Analysis: 1 µg from a representative lot immunoprecipitated acetyl-p53 in p53 transfected H1299 human lung cotransfected with or without hMOF (Prof. S. McMahon, Kimmel Cancer Center of Thomas Jefferson Medical College).

    Immunoprecipitation Analysis: 1.5 µg or 4.5 µg from a representative lot immunoprecipitated endogenous acetyl-p53 in HCT116 cell lysates, which were treated with a vehicle (DMSO) or camptothecin (CPT) (Prof. S. McMahon, Kimmel Cancer Center of Thomas Jefferson Medical College).

    Immunoprecipitation Analysis: 1 µg from a representative lot immunoprecipitated acetyl-p53 in H1299 cell lysates, which were transfected with either wild type p53, the 9 K/R mutant (all lysine residues except Lys120 mutated to arginine), the 10 K/R mutant (all lysine residues mutate including Lys 120), or empty vector, with or without hMOF (Prof. S. McMahon, Kimmel Cancer Center of Thomas Jefferson Medical College).
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to the AXIN1 interacting domain of human p53 acetylated at Lys120.
    表位 AXIN1 interacting domain
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 This antibody recognizes the AXIN1 interacting domain of p53 acetylated at Lys120.
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with Human. Predicted to react with Sheep, Porcine, Rabbit, and Canine based on 100% sequence homology. Other homologies: Mouse, Rat, Bovine, Feline, Zebrafish, and Equine (88% sequence homology).
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • ">NP_000537
    基因符号
    • P53
    • TP53
    纯化方法 Affinity purified
    UniProt编号
    • P04637
    产品使用声明
    质量保证 Evaluated by Dot Blot in non-acetylated and acetylated p53 peptides.

    Dot Blot Analysis: 1 µg/mL of this antibody detected acetyl-p53 in acetylated p53 peptides
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 200 µg

    merck millipore,默克密理博,ABE286,Anti-acetyl-p53 (Lys120) Antibody

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