merck millipore,默克密理博,516561,Pertussis Toxin, Bordetella pertussis, Glycerol Solution - CAS 70323-44-3

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merck millipore,默克密理博,516561,Pertussis Toxin, Bordetella pertussis, Glycerol Solution - CAS 70323-44-3 - Calbiochem
产品名称：Pertussis Toxin, Bordetella pertussis, Glycerol Solution - CAS 70323-44-3 - Calbiochem
产品型号：516561
A protein endotoxin that catalyzes ADP-ribosylation of guanine nucleotide-binding regulatory proteins.

merck millipore,默克密理博,516561,Pertussis Toxin, Bordetella pertussis, Glycerol Solution - CAS 70323-44-3 - Calbiochem

产品介绍

merck millipore,默克密理博,516561,Pertussis Toxin, Bordetella pertussis, Glycerol Solution - CAS 70323-44-3 - Calbiochem

重要规格表

CAS号
70323-44-3

描述
概述	A protein endotoxin that catalyzes ADP-ribosylation of guanine nucleotide-binding regulatory proteins. The holotoxin has five dissimilar subunits S-1, S-2, S-3, S-4, and S-5, in a molar ratio of 1:1:1:2:1, S-1 (A protomer) is responsible for the enzymatic activity of the toxin, and S-2, S-3, S-4, and S-5 form the B oligomer which is responsible for the toxins binding to the cell surface. NOTE: This product is not activated, hence for use in cell-free systems, activation is required.
产品目录编号	516561
品牌系列	Calbiochem®
同义词	Islet-activating Protein

参考
参考	Fryer, M.W. 1992. Neurosci. Lett. 146, 84. Gierschik, P. 1992. Curr. Topics Microbiol. Immunol. 175, 69. Harada, J., et al. 1992. Eur. J. Pharmacol. 227, 301. Hausman, S.Z., and Burns, D.L. 1992. J. Biol. Chem. 267, 13735. Kaslow, H.R., and Burns, D.L. 1992. FASEB J. 6, 2684. Zhu, J., et al. 1992. J. Pharmacol. Exp. Therap. 263, 1479 Kaslow, H.R., et al. 1987. Biochemistry 26, 123. Hewlett, E.L., et al. 1983. Infect. Immun. 40, 1198. Moss, J., et al. 1983. J. Biol. Chem. 258, 11879.

参考

Fryer, M.W. 1992. Neurosci. Lett. 146, 84.
Gierschik, P. 1992. Curr. Topics Microbiol. Immunol. 175, 69.
Harada, J., et al. 1992. Eur. J. Pharmacol. 227, 301.
Hausman, S.Z., and Burns, D.L. 1992. J. Biol. Chem. 267, 13735.
Kaslow, H.R., and Burns, D.L. 1992. FASEB J. 6, 2684.
Zhu, J., et al. 1992. J. Pharmacol. Exp. Therap. 263, 1479
Kaslow, H.R., et al. 1987. Biochemistry 26, 123.
Hewlett, E.L., et al. 1983. Infect. Immun. 40, 1198.
Moss, J., et al. 1983. J. Biol. Chem. 258, 11879.

产品信息
CAS号	70323-44-3
活性	≤35 pmol/min/µg in the presence of 1 µM calmodulin
具有ATP竞争性	N
形式	Liquid
配方	In 500 mM NaCl, 50 mM Tris, 10 mM glycine, 50% glycerol, pH 7.5.
可逆	N

生物信息
生物活性	≤1 ng/ml as determined in a clustering assay using CHO cells line
主靶	Guanine nucleotide-binding regulatory proteins
主靶IC₅₀	≤1 ng/ml as determined in a clustering assay using CHO cells line
纯度	Five distinct bands by SDS-PAGE
浓缩标签	Please refer to vial label for lot-specific concentration

理化信息
细胞可渗透	N
污染物	Adenylate cyclase.

GHS安全信息
RTECS	XW5883750

安全信息
R相	R: 23/24/25 Toxic by inhalation, in contact with skin and if swallowed.
S相	S: 36/37/39-45 Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

储存和货运信息
货运代码	Blue Ice Only
毒性	Toxic
有害材料注意事项：	Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
储存	-20°C
无需冷冻	No
特殊指南	A uniform suspension may be achieved by gentle mixing prior to use.
加拿大出口规定	Due to the country and/or U.S. state of origin of the animal material used in this product, this product may not be exported to Canada.