merck millipore,默克密理愽
  • merck millipore,默克密理博,513033,PD 168393 - CAS 194423-15-9 - Calbiochem

  • merck millipore,默克密理博,513033,PD 168393 - CAS 194423-15-9 - Calbiochem

    产品名称：PD 168393 - CAS 194423-15-9 - Calbiochem
    产品型号：513033
    A potent, cell-permeable, irreversible, ATP-competitive and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC₅₀ = 700 pM).

    merck millipore,默克密理博,513033,PD 168393 - CAS 194423-15-9 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,513033,PD 168393 - CAS 194423-15-9 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₇H₁₃BrN₄O194423-15-9
    描述
    概述 A potent, cell-permeable, irreversible, ATP-competitive and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC50 = 700 pM). Does not inhibit other protein kinases. Acts by binding to the catalytic domain of the EGFR with a 1:1 stoichiometry and alkylating Cys773. Excellent antitumor agent in vivo.
    产品目录编号 513033
    品牌系列 Calbiochem®
    同义词 4-[(3-Bromophenyl)amino]-6-acrylamidoquinazoline
    参考
    参考 Fry, D.W., et al. 1998. Proc. Natl. Acad. Sci USA 95, 12022.
    产品信息
    CAS号 194423-15-9
    具有ATP竞争性 Y
    形式 Yellow solid
    Hill配方 C₁₇H₁₃BrN₄O
    化学配方 C₁₇H₁₃BrN₄O
    Molar Mass 369.2
    可逆 N
    结构配方图像
    生物信息
    主靶 EGFR
    主靶IC50 700 pM against EGFR
    纯度 ≥98% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid freeze/thaw cycles of solutions.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,513033,PD 168393 - CAS 194423-15-9 - Calbiochem

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