merck millipore,默克密理愽
  • merck millipore,默克密理博,506282,PAD Inhibitor, Cl-amidine - Calbiochem

  • merck millipore,默克密理博,506282,PAD Inhibitor, Cl-amidine - Calbiochem

    产品名称：PAD Inhibitor, Cl-amidine - Calbiochem
    产品型号：506282
    The PAD Inhibitor, Cl-amidine controls the biological activity of PAD.

    merck millipore,默克密理博,506282,PAD Inhibitor, Cl-amidine - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,506282,PAD Inhibitor, Cl-amidine - Calbiochem

    重要规格表

    经验配方
    C₁₆H₂₀ClF₃N₄O₄
    描述
    概述 A cell-permeable compound that acts as a pan PAD inhibitor (IC50 = 0.8 µM, 6.2 µM and 5.9 µM for PAD1, PAD3, and PAD4, respectively) in enzymatic assays. It preferentially inactivates the calcium bound form of PAD4 in an irreversible manner, and is shown to complete with BAEE for the active site residue of this enzyme. A small but significant reduction in the efficiency of p300GDB-GRIP1 interaction is observed in transiently transfected CV-1 cells treated with Cl-amidine at concentrations between 25 µM and 200 µM, in vivo . Furthermore, this compound (200 µM) together with HDAC inhibitor SAHA (0.4 µM) has shown additive effects in inducing p21, GADD45, and PUMA expression and inhibiting cancer cell growth in a p53-dependent manner in U2OS cells.
    产品目录编号 506282
    品牌系列 Calbiochem®
    同义词 N-α-benzoyl-N5-(2-chloro-1-iminoethyl)-L-Orn amide
    参考
    参考 Knuckley, B., et al. 2010. Biochemistry 23, 4852.
    Li, P., et al. 2010. Oncogene 21, 3153.
    Luo, Y., et al. 2006. Biochemistry 39, 11727.
    产品信息
    形式 White solid
    Hill配方 C₁₆H₂₀ClF₃N₄O₄
    化学配方 C₁₆H₂₀ClF₃N₄O₄
    Molar Mass 424.8
    结构配方图像
    生物信息
    纯度 >95% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped with Blue Ice or with Dry Ice
    毒性 Regulatory Review
    储存 -20°C
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

    merck millipore,默克密理博,506282,PAD Inhibitor, Cl-amidine - Calbiochem

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