merck millipore,默克密理愽
  • merck millipore,默克密理博,481480,NF-κB SN50, Cell-Permeable Inhibitor Peptide - Calbiochem

  • merck millipore,默克密理博,481480,NF-κB SN50, Cell-Permeable Inhibitor Peptide - Calbiochem

    产品名称：NF-κB SN50, Cell-Permeable Inhibitor Peptide - Calbiochem
    产品型号：481480
    The NF-κB SN50, Cell-Permeable Inhibitor Peptide controls the biological activity of NF-κB. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

    merck millipore,默克密理博,481480,NF-κB SN50, Cell-Permeable Inhibitor Peptide - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,481480,NF-κB SN50, Cell-Permeable Inhibitor Peptide - Calbiochem

    重要规格表

    经验配方
    C₁₂₉H₂₃₀N₃₆O₂₉S
    描述
    概述 Contains the nuclear localization sequence (NLS) of the transcription factor NF-κB p50 linked to the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF). The N-terminal K-FGF h-region confers cell-permeability, while the NLS (360-369) inhibits translocation of the NF-κB active complex into the nucleus. In murine endothelial LE-II cells induced by LPS, NF-κB nuclear translocation is maximally inhibited at 18 µM.
    产品目录编号 481480
    品牌系列 Calbiochem®
    同义词 AAVALLPAVLLALLAPVQRKRQKLMP, NF-κB Activation Inhibitor VIII
    参考
    参考 Lin, Y.-Z., et al. 1995. J. Biol. Chem. 270, 14255.
    产品信息
    具有ATP竞争性 N
    声明 Sold under license of U.S. Patents 5,807,746 and 6,043,339 for research use only. Licenses for commercial manufacture, commercial use, diagnostics, or therapeutics may be obtained by contacting Vanderbilt University, Nashville, Tennessee.
    形式 Lyophilized
    配方 Supplied as a trifluoroacetate salt.
    Hill配方 C₁₂₉H₂₃₀N₃₆O₂₉S
    化学配方 C₁₂₉H₂₃₀N₃₆O₂₉S
    Molar Mass 2781.5
    吸湿 Hygroscopic
    肽序列 H-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Val-Gln-Arg-Lys-Arg-Gln-Lys-Leu-Met-Pro-OH
    可逆 N
    基于肽含量售出 Yes
    生物信息
    主靶 translocation of the NF-κB active complex into the nucleus
    纯度 ≥97% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 H₂O
    肽含量 Yes
    肽序列 H-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Val-Gln-Arg-Lys-Arg-Gln-Lys-Leu-Met-Pro-OH
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 -20°C
    吸湿 Hygroscopic
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid freeze/thaw cycles of solutions.

    merck millipore,默克密理博,481480,NF-κB SN50, Cell-Permeable Inhibitor Peptide - Calbiochem

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