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merck millipore,默克密理博,481418,NEMO NOA Peptide, Cell-Permeable, A-UBI - Calbiochem
产品名称：NEMO NOA Peptide, Cell-Permeable, A-UBI - Calbiochem
产品型号：481418
The NF-κB Activation Inhibitor VIII, A-UBI controls the biological activity of NF-κB. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.
merck millipore,默克密理博,481418,NEMO NOA Peptide, Cell-Permeable, A-UBI - Calbiochem
- 产品介绍
重要规格表
经验配方 C₂₁₅H₃₄₇N₇₁O₅₀S₁ plus TFA and water 描述 概述 A cell-permeable 37-mer peptide derived from the NEMO NOA ubiquitin binding site (294-314 of mouse sequence with D304R), and fused with an Antennapedia cell penetrating protein (A) at the N-terminus. It is shown to attenuate NF-κB activation via blocking interactions between K63-polyubiquitin chains and the NOA ubiquitin binding domain of NEMO (Kd = 17 µM for CC2-LZ/A-UBI complex). The biotin-labled A-UBI specifically inhibits the LPS-induced NF-κB activation (IC50 = 1.1 µM, compared with 23 µM for IKKβ derived A-NBD) and TNF-α induced NF-κB activation (IC50 = 21 µM) in 70Z/3-C3 pre-B lymphocytes. It displays an inhibitory effect on nuclear translocation of NF-κB p65 and IKK kinase activity at 10 µM, but does not significantly affect other signaling pathways such as MAPK/ERK, MAPK/JNK, NF-κB and NFAT. 产品目录编号 481418 品牌系列 Calbiochem®
同义词 NEMO Ubiquitin Binding Domain Inhibitor 参考 参考 Chiaravalli, J., et al. 2011. Biochem. Pharm. 82, 1163. 产品信息 形式 White powder Hill配方 C₂₁₅H₃₄₇N₇₁O₅₀S₁ plus TFA and water 化学配方 C₂₁₅H₃₄₇N₇₁O₅₀S₁ plus TFA and water Molar Mass 4758.59 肽序列 RQIKIWFQNRRMKWKKLKAQADIYKARFQAERHAREK 生物信息 纯度 ≥95% by HPLC 理化信息 溶解度 H₂O 肽序列 RQIKIWFQNRRMKWKKLKAQADIYKARFQAERHAREK 储存和货运信息 货运代码 Shipped with Blue Ice or with Dry Ice
毒性 Standard Handling
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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