merck millipore,默克密理博,05-369X-555,Anti-Na+/K+ ATPase α-1 Antibody, clone C464.6, Alexa Fluor 555

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merck millipore,默克密理博,05-369X-555,Anti-Na+/K+ ATPase α-1 Antibody, clone C464.6, Alexa Fluor 555
产品名称：Anti-Na+/K+ ATPase α-1 Antibody, clone C464.6, Alexa Fluor 555
产品型号：05-369X-555
Detect Na+/K+ ATPase α-1 using this Anti-Na+/K+ ATPase α-1 Antibody, clone C464.6, Alexa Fluor 555 validated for use in FC, IF & WB.

merck millipore,默克密理博,05-369X-555,Anti-Na+/K+ ATPase α-1 Antibody, clone C464.6, Alexa Fluor 555

产品介绍

merck millipore,默克密理博,05-369X-555,Anti-Na+/K+ ATPase α-1 Antibody, clone C464.6, Alexa Fluor 555

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
Xn, Ca, H, M, Mk, Po, R, Rb, Sh	WB, FC	M	AlexaFluor®555	Monoclonal Antibody

描述
产品目录编号	05-369X-555
品牌系列	Upstate
商名	Upstate
描述	Anti-Na+/K+ ATPase α-1 Antibody, clone C464.6, Alexa Fluor® 555

产品信息
格式	AlexaFluor®555
控制	Included Negative Control: Catalog # 16-239, Alexa Fluor® 555-conjugated Normal Mouse IgG.
演示	25µg Alexa Fluor® 555-conjugated protein G purified mouse IgG1κ in 100µl of PBS containing 1% BSA, 0.05% Tween®-20, 0.05% sodium azide. Liquid at 4°C.

应用
应用	Detect Na+/K+ ATPase α-1 using this Anti-Na+/K+ ATPase α-1 Antibody, clone C464.6, Alexa Fluor 555 validated for use in FC, IF & WB.
主要应用	Western Blotting Flow Cytometry

生物信息
免疫原品种	Purified Na+/K+ ATPase isolated from membrane fractions of rabbit kidney outer medulla.
克隆	C464.6
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Mouse
特异性	Specific for the α-1 subunit isoform.
同种型	IgG1
品种反应性	XenopusCanineHumanMouseMonkeyPigRatRabbitSheep
抗体类型	Monoclonal Antibody
Entrez基因编号	NM_152296.3
Entrez基因汇总	The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 3 subunit.
基因符号	Na ATP1A3 MGC13276 RDP IIIsubunit). DYT12 +K
纯化方法	Protein G purfied
UniProt编号	Q9N0Z6
UniProt汇总	FUNCTION: SwissProt: P13637 # This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. SIZE: 1013 amino acids; 111749 Da SUBUNIT: Composed of three subunits: alpha (catalytic), beta and gamma. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. DISEASE: SwissProt: P13637 # Defects in ATP1A3 are the cause of dystonia-12 (DYT12) [MIM:128235]; also known as rapid-onset dystonia parkinsonism (RDP). DYT12 is an autosomal dominant form of dystonia- parkinsonism characterized by an unusually rapid evolution of signs and symptoms. Affected persons develop dystonia and parkinsonism between 14 and 45 years of age. The sudden onset of symptoms over hours to a few weeks, often associated with physical or emotional stress, suggests a trigger initiating a nervous system insult resulting in permanent neurologic disability. SIMILARITY: SwissProt: P13637 ## Belongs to the cation transport ATPase (P-type) family. Type IIC subfamily.

产品使用声明
质量保证	Immunoblot Analysis: 2µg/ml of this lot detected α-1 subunit in 40μg of rat brain microsomal preparation. Immunocytochemistry: 2µg/ml of this lot showed positive immunostaining for α-1 subunit in Colo 205 cells. Flow Cytometry: 0.2μg of this lot detected α-1 subunit in fixed NCI H292 cells (see data).
使用声明	Alexa Fluor® is a registered trademark of Molecular Probes, Inc. Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

产品使用声明

质量保证

Immunoblot Analysis: 2µg/ml of this lot detected α-1 subunit in 40μg of rat brain microsomal preparation.

Immunocytochemistry: 2µg/ml of this lot showed positive immunostaining for α-1 subunit in Colo 205 cells.

Flow Cytometry: 0.2μg of this lot detected α-1 subunit in fixed NCI H292 cells (see data).

使用声明

Alexa Fluor® is a registered trademark of Molecular Probes, Inc.
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Do Not Freeze. Do not store the material diluted. Stable for 1 year at 4°C from date of shipment. For maximum recovery of product, centrifuge original vial prior to removing cap.