merck millipore,默克密理愽
  • merck millipore,默克密理博,481417,CRAC Channel Inhibitor IV, EVP4593 - Calbiochem

  • merck millipore,默克密理博,481417,CRAC Channel Inhibitor IV, EVP4593 - Calbiochem

    产品名称：CRAC Channel Inhibitor IV, EVP4593 - Calbiochem
    产品型号：481417
    The NF-κB Activation Inhibitor VIII, EVP4593 controls the biological activity of NF-κB. This small molecule/inhibitor is primarily used for Neuroscience applications.

    merck millipore,默克密理博,481417,CRAC Channel Inhibitor IV, EVP4593 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,481417,CRAC Channel Inhibitor IV, EVP4593 - Calbiochem

    重要规格表

    经验配方
    C₂₂H₂₀N₄O
    描述
    概述 A cell-permeable quinazoline derivative that blocks PMA/PHA-induced NF-κB activation in Jurkat cells (IC50 = 11 nM), but has no effect on PKC kinase, and exhibits an anti-inflammatory effect on carrageenin-induced paw edema in rats (1 mg/kg, i.p.). In addition, it is shown to inhibit the store-operated calcium entry (SOC) pathway possibly by targeting TRPC1 containing heteromeric channels in Huntington Disease (HD) neurons (SK-N-SH cells transfected with mutant Huntingtin Htt-138Q) at 300 nM. It displays neuroprotective effects in YAC128 MSN mice neurons from glutamate toxicity dose-dependently from 30 nM to 3 µM, which is consistent with TRPC1 knockdown effects, and attenuates the progressive decline in the climbing speed of the HD Drosophila, dose-dependently from 100 µM to 400 µM.
    产品目录编号 481417
    品牌系列 Calbiochem®
    同义词 N4-(4-phenoxyphenethyl)quinazoline-4,6-diamine, SOC Inhibitor
    参考
    参考 Wu, J., et al. 2011. Chem Biol. 18, 777.
    Tobe, M., et al. 2003. Bioorg. Med. Chem. 11, 383.
    Tobe, M., et al. 2003. Bioorg. Med. Chem. 11, 3869.
    产品信息
    形式 Yellow powder
    Hill配方 C₂₂H₂₀N₄O
    化学配方 C₂₂H₂₀N₄O
    Molar Mass 356.42
    结构配方图像
    生物信息
    纯度 ≥98% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Regulatory Review
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,481417,CRAC Channel Inhibitor IV, EVP4593 - Calbiochem

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