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品种反应性 主要应用 宿主 格式 抗体类型 M, H WB, ICC, IHC M Purified Monoclonal Antibody 描述 产品目录编号 MAB4343 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-SOX-2 Antibody 背景信息 Sox-2 plays a key role in embryonic stem cell development, and has been shown to help stem cells maintain pluripotent potential. It has also been shown to be associated with uncommitted dividing stem cell and precursor cells of the developing CNS. 产品信息 格式 Purified 演示 Immunoglobulin purified from ascites by protein A affinity chromatography and presented as a liquid in 0.02 M phosphate buffer, pH 7.6, with 0.25 M NaCl. Contains 0.1% sodium azide. 应用 应用 Anti-SOX-2 Antibody detects level of SOX-2 & has been published & validated for use in IC, IH & WB. 主要应用 - Western Blotting
- Immunocytochemistry
- Immunohistochemistry
生物信息 免疫原品种 Recombinant GST Fusion protein. 克隆 6F1.2 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 同种型 IgG2b 品种反应性 MouseHuman 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_003106.2
Entrez基因汇总 This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). 基因符号 - MCOPS3
- SOX2
- ANOP3
- MGC2413
UniProt编号 - P48431
UniProt汇总 FUNCTION: SwissProt: P48431 # Can form ternary complexes with OCT-1 or OCT-3 but acts as a transcriptional activator of FGF-4 enhancer DNA sequences only in conjunction with OCT-3 (By similarity).
SIZE: 317 amino acids; 34310 Da
SUBCELLULAR LOCATION: Nucleus.
DISEASE: SwissProt: P48431 # Defects in SOX2 are the cause of microphthalmia syndromic type 3 (MCOPS3) [MIM:206900]. MCOPS3 is characterized by the association of microphthalmia or clinical anophthalmia with anomalies such as microcephaly, short stature, hypogonadotropic hypogonadism, esophageal atresia and neurologic manifestations.
SIMILARITY: SwissProt: P48431 ## Contains 1 HMG box DNA-binding domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months. 包装信息 数量 100 µg
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