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经验配方 C₃₅H₂₀N₄O₂₁S₆ · 6Na 描述 概述 A suramin analog that acts as a selective and direct G-protein antagonist for α-subunits of the Go/Gi group (EC50 ~ 300 nM). Suppresses GTPγS binding to recombinant G-protein α-subunits. Acts by inhibiting the formation of the agonist-specific ternary complex (agonist/receptor/G-protein). NF023 does not interfere with the interaction between α-subunits and βγ-dimer but competes with the effector binding site. Also a P2X receptor antagonist (IC50 = 240 nM for P2X1; 8.5 µM for P2X3 receptor in rat muscle). Causes a concentration dependent inhibition of excitatory junction potentials (IC50 = 4.8 pM). 产品目录编号 480415 品牌系列 Calbiochem®
同义词 8,8ʹ-[Carbonylbis(imino-3,1-phenylene)]bis-(1,3,5-naphthalenetrisulfonic Acid), 6Na, P2X Antagonist I, Purinergic Receptor P2X Antagonist I 参考 参考 Snedden, P., et al. 2000. Br. J. Pharmacol. 129, 1089.
Soto, F., et al. 1999. Neuropharmacology 38, 141.
Beindle, W., et al. 1996. Mol. Pharmacol. 50, 415.
Freissmuth, M., et al. 1996. Mol. Pharmacol. 49, 602.产品信息 具有ATP竞争性 N 形式 Yellow solid Hill配方 C₃₅H₂₀N₄O₂₁S₆ · 6Na 化学配方 C₃₅H₂₀N₄O₂₁S₆ · 6Na Molar Mass 1162.9 吸湿 Hygroscopic
可逆 N 结构配方图像 生物信息 主靶 α-subunits of the Go/Gi group of G-protein 主靶IC50 240 nM for P2X1; 8.5 µM for P2X3 receptor in rat muscle; 4.8 pM in the inhibition of excitatory junction potentials; EC50 ~ 300 nM as G-protein antagonist for α-subunits of the Go/Gi group 纯度 ≥95% by HPLC 理化信息 细胞可渗透 N 溶解度 H₂O 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
吸湿 Hygroscopic
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Avoid freeze/thaw cycles of solutions. 包装信息 惰性气体下包装 Packaged under inert gas
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