merck millipore,默克密理愽
  • merck millipore,默克密理博,475965,c-Myc Inhibitor III, Mycro2 - Calbiochem

  • merck millipore,默克密理博,475965,c-Myc Inhibitor III, Mycro2 - Calbiochem

    产品名称：c-Myc Inhibitor III, Mycro2 - Calbiochem
    产品型号：475965
    The c-Myc Inhibitor III, Mycro2 controls the biological activity of c-Myc.

    merck millipore,默克密理博,475965,c-Myc Inhibitor III, Mycro2 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,475965,c-Myc Inhibitor III, Mycro2 - Calbiochem

    重要规格表

    经验配方
    C₁₇H₁₁F₃N₄OS₂
    描述
    概述 A cell-permeable pyrazolopyrimidine-carboxamide that selectively inhibits c-Myc-Max dimer DNA binding activity (IC50 = 23 µM) by preventing c-Myc-Max heterodimer formation, while affecting Max, Jun, C/EBPα homodimers, or Jun-Fos heterodimer DNA binding only at much higher concentrations (IC50 = ≥54 µM). Shown to selectively inhibit c-Myc-Max-dependent transcription (by 77% against E-Box promoter-driven reporter transcription at 10 µM), cancer proliferation, and anchorage-independent colony formation (Effective conc. 10-20 µM).
    产品目录编号 475965
    品牌系列 Calbiochem®
    同义词 5-(Thiophen-2-yl)-N-(thiophen-2-ylmethyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide
    参考
    参考 Kiessling, A., et al. 2006. Chem. Biol. 13, 745.
    产品信息
    形式 Yellow solid
    Hill配方 C₁₇H₁₁F₃N₄OS₂
    化学配方 C₁₇H₁₁F₃N₄OS₂
    Molar Mass 408.4
    可逆 Y
    结构配方图像
    生物信息
    主靶 α-helical dimerization motifs of c-Myc/Max factors
    主靶IC50 IC₅₀ = 23 and 54 µM for c-Myc/Max and Max/Max dimerization
    副靶 α-helical dimerization motifs of Max/Max factors
    纯度 ≥99% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,475965,c-Myc Inhibitor III, Mycro2 - Calbiochem

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