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经验配方 C₂₃H₁₅N₃O₄ 描述 概述 A cell-permeable, of 8-Hydroxy analog 1541 (Cat. No. 529662) that is shown to selectively activate procaspase-3 (EC50 = 1.3 µM), but not procaspase-6. Both 1541 and 1541B are shown to effectively induce apoptosis in various cancer cell lines with comparable potencies, indicating that caspase-3 activation alone is as effective in cell death induction as simultaneous activations of caspase-3/-6 among cells tested. 1541B is expected to inhibit the activity of mature/active caspase-3 and exhibit reduced procaspase-3 activation at high concentrations. 产品目录编号 264158 品牌系列 Calbiochem®
同义词 Procaspase-3 Activator III, 8-Hydroxy-2-oxo-2H-chromene-3-carboxylic acid-(3-imidazo[1,2-a]pyridin-2-yl-phenyl)-amide, Caspase-3 Inhibitor XVI 参考 参考 Wolan, D.W., et al. 2009. Science 326, 853. 产品信息 形式 Pale yellow solid Hill配方 C₂₃H₁₅N₃O₄ 化学配方 C₂₃H₁₅N₃O₄ Molar Mass 397.4 结构配方图像 生物信息 纯度 ≥95% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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