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merck millipore,默克密理博,475958,c-Raf Inhibitor - Calbiochem
产品名称：c-Raf Inhibitor - Calbiochem
产品型号：475958
The c-Raf Inhibitor controls the biological activity of c-Raf. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.
merck millipore,默克密理博,475958,c-Raf Inhibitor - Calbiochem
- 产品介绍
重要规格表
经验配方 C₂₃H₁₉F₃N₈O 描述 概述 A cell-permeable pyrazoloimidazole phenyl urea derivative that acts as a selective type II inhibitor of c-Raf. It shows an IC50 value of 50 nM in an enzymatic assay, and comparable anti-proliferative activities to sorafenib against A375P (GI 50 = 2.68 µM) and WM3629 (GI50 = 0.86 µM) human melanoma cell lines. When screening against a panel of 30 different kinases at a concentration of 10 µM, it exerts an inhibitory activity of 96% on c-Raf, but below 50% for most of the other kinases. 产品目录编号 475958 品牌系列 Calbiochem®
同义词 1-(3-(1,4-dihydroimidazo[4,5-c]pyrazol-5-yl)-4-methylphenyl)-3-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)urea, c-Raf Inhibitor 参考 参考 Yu, H., et al. 2010. Bioorg. Med. Chem. Lett. 20, 3805. 产品信息 形式 Off white solid Hill配方 C₂₃H₁₉F₃N₈O 化学配方 C₂₃H₁₉F₃N₈O Molar Mass 480.45 结构配方图像 生物信息 纯度 ≥95% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
上一件merck millipore产品：merck millipore,默克密理博,496150,Omi/HtrA2 Protease Inhibitor, Ucf-101 - CAS 313649-08-0 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,F84-DL3,Manifold for CellASIC ONIX, for use with F84 plates, for DIC viewing
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