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经验配方 CAS号 C₂₅H₃₉N₃O₅ 133407-86-0 描述 概述 Potent reversible proteasome inhibitor (Ki = 21 nM and 35 nM for 20S and 26S proteasome, respectively). Specifically inhibits the chymotrypsin-like activity of the proteasome and induces apoptosis in Rat-1 and PC12 cells. 产品目录编号 474780 品牌系列 Calbiochem®
同义词 Carbobenzoxy-L-leucyl-L-leucyl-L-norvalinal, Z-LL-Nva-CHO, Proteasome Inhibitor XII 参考 参考 Lopes, U.G., et al. 1997. J. Biol. Chem. 272, 12893.
Lee, D.H., and Goldberg, A.L. 1996. J. Biol. Chem. 271, 27280.
Palombella, V.J., et al. 1994. Cell 78, 773. Rock, K.L., et al. 1994. Cell 78, 761.
Vinitsky, A., et al. 1992. Biochemistry 31, 9421.产品信息 CAS号 133407-86-0 具有ATP竞争性 N 形式 White solid Hill配方 C₂₅H₃₉N₃O₅ 化学配方 C₂₅H₃₉N₃O₅ Molar Mass 461.6 肽序列 Z-Leu-Leu-Nva-CHO 可逆 Y 结构配方图像 生物信息 主靶 20S proteasome 主靶Ki 21 nM and 35 nM for 20S and 26S proteasome, respectively 纯度 ≥90% by HPLC 理化信息 细胞可渗透 N 溶解度 DMSO 肽序列 Z-Leu-Leu-Nva-CHO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
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