- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
-
-
merck millipore,默克密理博,46-641MAG,MILLIPLEX MAP Phospho STAT5A/B (Tyr694/699) Magnetic Bead MAPmate - Cell Signaling Single Plex or Multiplex Assay
产品名称：MILLIPLEX MAP Phospho STAT5A/B (Tyr694/699) Magnetic Bead MAPmate - Cell Signaling Single Plex or Multiplex Assay
产品型号：46-641MAG
This MILLIPLEX MAP Phospho STAT5A/B (Tyr694/699) Magnetic Bead MAPmate is a Cell Signaling single plex assay. The analyte available for this kit is STAT5A/B (Tyr694/699).
merck millipore,默克密理博,46-641MAG,MILLIPLEX MAP Phospho STAT5A/B (Tyr694/699) Magnetic Bead MAPmate - Cell Signaling Single Plex or Multiplex Assay
- 产品介绍
- merck millipore,默克密理博,46-641MAG,MILLIPLEX MAP Phospho STAT5A/B (Tyr694/699) Magnetic Bead MAPmate - Cell Signaling Single Plex or Multiplex Assay
重要规格表
可用的分析物 品种反应性 主要应用 检测方法 STAT5A/B (Tyr694/699) R, H, M Mplex Luminex xMAP 描述 产品目录编号 46-641MAG 商名 - MILLIPLEX
描述 MILLIPLEX MAP Phospho STAT5A/B (Tyr694/699) Magnetic Bead MAPmate - Cell Signaling Single Plex or Multiplex Assay 背景信息 STAT5A/B
• Also known as “signal transducer and activator of transcription 5,” referring to two highly related proteins, STAT5A and STAT5B
• Plays a role in cytosolic signaling, cell growth, proliferation, differentiation, and inflammation
• Implicated in a wide range of cancers产品信息 检测方法 Luminex xMAP 配置 Single Plex 板面类型 Cell Signaling 应用 应用 This MILLIPLEX MAP Phospho STAT5A/B (Tyr694/699) Magnetic Bead MAPmate is a Cell Signaling single plex assay. The analyte available for this kit is STAT5A/B (Tyr694/699). 主要应用 - Multiplexing
应用说明 • An overnight (4°C) incubation is recommended for best results
• This assay requires 25 µL diluted cell lysate per well
• Please consult the buffer compatibility chart or protocol for appropriate buffer choice
• 1 - 25 μg cell lysate/well (recommended starting concentration is 20 μg)生物信息 品种反应性 RatHumanMouse 可用的分析物 - STAT5A/B (Tyr694/699)
Entrez基因编号 - NM_003152.2
Entrez基因汇总 The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. 基因符号 - STAT5
- STAT5A
- MGF
UniProt编号 - P51692
- P42229
UniProt汇总 FUNCTION: SwissProt: P51692 # Carries out a dual function: signal transduction and activation of transcription. Binds to the GAS element and activates PRL-induced transcription.
SIZE: 787 amino acids; 89866 Da
SUBUNIT: Forms a homodimer or a heterodimer with a related family member. Binds NR3C1 (By similarity). Interacts with NCOA1, NMI and SOCS7.
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). Note=Translocated into the nucleus in response to phosphorylation (By similarity).
PTM: Tyrosine phosphorylated (By similarity).
DISEASE: SwissProt: P51692 # Defects in STAT5B are the cause of Laron type dwarfism II (LTD2) [MIM:245590]; also known as Laron syndrome type II or Laron syndrome due to a post-receptor defect. The phenotypic features are consistent with growth hormone deficiency in the presence of normal to elevated circulating concentrations of growth hormone, and resistance to hexogeneous hormone therapy.
SIMILARITY: SwissProt: P51692 ## Belongs to the transcription factor STAT family. & Contains 1 SH2 domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Recommended storage for kit components is 2 - 8°C 包装信息 数量 96-well plate
上一件merck millipore产品：merck millipore,默克密理博,AB5613,Anti-Brain Derived Neurotrophic Factor Antibody, pro
下一件merck millipore产品：merck millipore,默克密理博,NE1013,Anti-PGP9.5 (176-191) Rabbit pAb
相关产品
merck millipore,默克密理博,CBL402-KC,Mouse Anti-HPV-16 Late 1 Protein (1mg) KC
merck millipore,默克密理博,MAB201-KC,Anti-Rb IgG Light Chain, MS, (KC)
merck millipore,默克密理博,HTS066RTA,Ready-to-Assay™ Y2 Neuropeptide Receptor Frozen Cells
merck millipore,默克密理博,AB5613,Anti-Brain Derived Neurotrophic Factor Antibody, pro
merck millipore,默克密理博,NE1013,Anti-PGP9.5 (176-191) Rabbit pAb
merck millipore,默克密理博,14-595M,PP1α Protein, 250 µg
merck millipore,默克密理博,400091,HIF-Hydroxylase Inhibitor, DMOG - CAS 89464-63-1 - Calbiochem
merck millipore,默克密理博,SCM087,Mouse iPS Reprogramming Boost Supplement
merck millipore,默克密理博,SCM009,Rat Neural Stem Cell Expansion Medium