merck millipore,默克密理博,400091,HIF-Hydroxylase Inhibitor, DMOG - CAS 89464-63-1

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Merck Millipore 默克密理愽

merck millipore,默克密理博,400091,HIF-Hydroxylase Inhibitor, DMOG - CAS 89464-63-1 - Calbiochem

经验配方	CAS号
C₆H₉NO₅	89464-63-1

描述
概述	A cell-permeable 2-OG (2-oxoglutarate) analog that is expected to act as a competitive inhibitor against all 2-OG-dependent dioxygenases. Effectively upregulates normoxia HIF-α transcription activity (effective conc. = 1 mM in cultures) by inhibiting HIF-PH- (HIF-α-prolyl hydroxylase) catalyzed ODD (oxygen-dependent degradation domain) Prolyl hydroxylation (Pro⁵⁶⁴ and Pro⁵³⁰ in HIF-1α and HIF-2α, respectively) and aspartyl/asparanginyl β-hydroxylase-catalyzed CAD Asp hydroxylation (Asn⁸⁰³ and Asn⁸⁵¹ in HIF-1α and HIF-2α, respectively), resulting in a blockage of pVHL (von Hippel-Lindau) ubiquitin ligase complex-mediated HIF-α degradation and a simultaneous promotion of HIF CAD (COOH-terminal activation domain) p300/CBP association. DMOG is also demonstrated to augment artery ligation-induced up-regulation of HIF-1α and FLK (by 100% and 40%, respectively, in 11 days; 8 mg/0.5 ml/animal/i.p.; q.o.d.) in muscle tissues in a murine ischaemic model in vivo.
产品目录编号	400091
品牌系列	Calbiochem®
同义词	HIF Prolyl Hydroxylase Inhibitor I, HIF Aspartyl β-Hydroxylase Inhibitor, HIF Asparanginyl β-Hydroxylase Inhibitor, N-(Methoxyoxoacetyl)-glycine methyl ester, Dimethyloxalylglycine

参考
参考	Pollard, P.J., et al. 2008. Biochem. J. 416, 387. Chen, H., et al. 2006. Cancer Res. 66, 9009. Milkiewicz, M., et al. 2004. J. Physiol. 560, 21. Lando, D., et al. 2002. Science 295, 858. Jaakkola, P., et al. 2001. Science 292, 468.

生物信息
纯度	≥98% by HPLC

理化信息
溶解度	DMSO

储存和货运信息
货运代码	Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性	Regulatory Review
储存	+2°C to +8°C
吸湿	Hygroscopic
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

merck millipore,默克密理博,400091,HIF-Hydroxylase Inhibitor, DMOG - CAS 89464-63-1 - Calbiochem

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