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merck millipore,默克密理博,46-606MAG,MILLIPLEX MAP Total EGFR Magnetic Bead MAPmate - Cell Signaling Single Plex or Multiplex Assay
产品名称：MILLIPLEX MAP Total EGFR Magnetic Bead MAPmate - Cell Signaling Single Plex or Multiplex Assay
产品型号：46-606MAG
This MILLIPLEX MAP Total EGF Receptor MAPmate is a Cell Signaling multiplex assay.
merck millipore,默克密理博,46-606MAG,MILLIPLEX MAP Total EGFR Magnetic Bead MAPmate - Cell Signaling Single Plex or Multiplex Assay
- 产品介绍
- merck millipore,默克密理博,46-606MAG,MILLIPLEX MAP Total EGFR Magnetic Bead MAPmate - Cell Signaling Single Plex or Multiplex Assay
重要规格表
可用的分析物 品种反应性 主要应用 检测方法 EGFR (Total) H Mplex Luminex xMAP 描述 产品目录编号 46-606MAG 商名 - MILLIPLEX
描述 MILLIPLEX MAP Total EGFR Magnetic Bead MAPmate - Cell Signaling Single Plex or Multiplex Assay 背景信息 • A cell surface receptor, also known as “epidermal growth factor receptor,” ErbB-1, or HER1
• Activated when specific ligands bind, epidermal growth factor (EGF) or transforming growth factor α (TGFα), among others
• Implicated in various types of cancers, and as a result, EGFR has been the target for a lot of cancer drug development产品信息 检测方法 Luminex xMAP 配置 Single Plex 板面类型 Cell Signaling 应用 应用 This MILLIPLEX MAP Total EGF Receptor MAPmate is a Cell Signaling multiplex assay. 主要应用 - Multiplexing
应用说明 • An overnight (4°C) incubation is recommended for best results
• This assay requires 25 µL diluted cell lysate per well
• Please consult the buffer compatibility chart or protocol for appropriate buffer choice
• 1 - 25 μg cell lysate/well (recommended starting concentration is 20 μg)生物信息 品种反应性 Human 可用的分析物 - EGFR (Total)
Entrez基因编号 - NM_138957.2
- NM_002745.4
Entrez基因汇总 The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. 基因符号 - p41mapk
- MAPK1
- PRKM2
- MAPK2
- p42-MAPK
- p38
- ERK
- P42MAPK
- ERK2
- p40
- PRKM1
- p41
- ERK-2
- ERT1
UniProt编号 - P28482
UniProt汇总 FUNCTION: SwissProt: P28482 # Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1 (By similarity). Phosphorylates heat shock factor protein 4 (HSF4).
COFACTOR: Magnesium (By similarity).
SIZE: 360 amino acids; 41390 Da
SUBUNIT: Interacts with MORG1 (By similarity). Binds to HIV-1 Nef through its SH3 domain. This interaction inhibits its tyrosine- kinase activity. Interacts with HSF4.
DOMAIN: SwissProt: P28482 The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
PTM: Dually phosphorylated on Thr-185 and Tyr-187, which activates the enzyme.
SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. & Contains 1 protein kinase domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Recommended storage for kit components is 2 - 8°C 包装信息 数量 96-well plate
上一件merck millipore产品：merck millipore,默克密理博,MABN666,Anti-TRIP8b Antibody, clone N212A/34
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