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品种反应性 主要应用 宿主 格式 抗体类型 R, H, M IHC Rb Serum Polyclonal Antibody 描述 产品目录编号 AB5404 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Neurturin Antibody 产品信息 格式 Serum 演示 Rabbit serum. Lyophilized. Contains no preservative. Reconstitute with 50 μL of sterile distilled water. Centrifuge if necessary to remove any residue. 应用 应用 Anti-Neurturin Antibody detects level of Neurturin & has been published & validated for use in IH. 主要应用 - Immunohistochemistry
应用说明 Immunohistochemistry: 1:1,000-1:2,000
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Recombinant human Neurturin. 宿主 Rabbit 特异性 Neurturin. No cross reactivity with GDNF. 品种反应性 RatHumanMouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_004558.2
Entrez基因汇总 Neurturin is a member of the TGF-beta subfamily, TRN. This gene signals through RET and a GPI-linked coreceptor, and promotes survival of neuronal populations. A neurturin mutation has been described in a family with Hirschsprung Disease. 基因符号 - neurturin
- NRTN
- NTN
UniProt编号 - Q99748
UniProt汇总 FUNCTION: SwissProt: Q99748 # Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells.
SIZE: 197 amino acids; 22405 Da
SUBUNIT: Homodimer; disulfide-linked.
SUBCELLULAR LOCATION: Secreted.
DISEASE: SwissProt: Q99748 # Defects in NRTN are a cause of Hirschsprung disease (HSCR) [MIM:142623]. In association with mutations of RET gene, and possibly with other loci, defects in NRTN are involved in Hirschsprung disease. This genetic disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction.
SIMILARITY: SwissProt: Q99748 ## Belongs to the TGF-beta family. GDNF subfamily.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain lyophilized material at -20°C to -70°C for up to 6 months. After reconstitution maintain frozen at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. 包装信息 数量 50 µL
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