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merck millipore,默克密理博,445865,mGluR5 Ligand, CDPPB - CAS 781652-57-1 - Calbiochem
产品名称：mGluR5 Ligand, CDPPB - CAS 781652-57-1 - Calbiochem
产品型号：445865
A pyrazole amide compound that crosses the blood-brain barrier and acts as a potent, selective, reversible, positive allosteric modulator for metabotropic glutamate receptor subtype 5 (mGluR5).
merck millipore,默克密理博,445865,mGluR5 Ligand, CDPPB - CAS 781652-57-1 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₂₃H₁₆N₄O 781652-57-1 描述 概述 A pyrazole amide compound that crosses the blood-brain barrier and acts as a potent, selective, reversible, positive allosteric modulator for metabotropic glutamate receptor subtype 5 (mGluR5). Also exerts anti-psychotic-like effects. Reported to potentiate the response to glutamate (~300 nM) in CHO-mGluR5 cells (EC50 = 10 nM for human, 4-fold potentiation; 20 nM for rat, 4.3-fold potentiation) and reverse amphetamine-induced disruption of pre-pulse inhibition (PPI) in rats. Specificity was determined using a panel of kinases and receptors. Does not potentiate the activity of other glutamate receptors. 产品目录编号 445865 品牌系列 Calbiochem®
同义词 3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide 参考 参考 Kinney, G.G., et al. 2005. J. Pharmacol. Exp. Ther. 313, 199.
Lindsley, C.W., et al. 2004. J. Med. Chem. 47, 5825.产品信息 CAS号 781652-57-1 具有ATP竞争性 N 形式 Off-white solid Hill配方 C₂₃H₁₆N₄O 化学配方 C₂₃H₁₆N₄O Molar Mass 364.4 可逆 Y 结构配方图像 生物信息 主靶 Metabotropic glutamate receptor subtype 5 (mGluR5) 主靶IC50 EC50 = 10 nM in potentiating the response to glutamate (~300 nM) in CHO-mGluR5 cells for human, 4-fold potentiation; 20 nM for rat, 4.3-fold potentiation 纯度 ≥99% by HPLC 理化信息 细胞可渗透 N 溶解度 DMSO 储存和货运信息 货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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