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merck millipore,默克密理博,444293,MMP-9 Inhibitor II - Calbiochem
产品名称：MMP-9 Inhibitor II - Calbiochem
产品型号：444293
The MMP-9 Inhibitor II controls the biological activity of MMP-9. This small molecule/inhibitor is primarily used for Biochemicals applications.
merck millipore,默克密理博,444293,MMP-9 Inhibitor II - Calbiochem
- 产品介绍
重要规格表
经验配方 C₁₆H₁₇F₂N₃O₃S 描述 概述 This compound is a cell-permeable, selective, and reversible thiopyrimidone MMP-9 allosteric inhibitor that binds specifically to the non-catalytic site of MMP-9 at the PEX domain with a Kd = 2.1 µM and thereby disrupts MMP-9 homodimerization and its cross-talk with CD44 and the EGFR-MAPK signaling pathway. It does not bind to the PEX domain of MMP-2 or MT1-MMP and it is shown to decrease MMP-9 mediated cell migration in COS-1 cells at 100 µM. Also, it inhibits cell migration and invasion of HT-1080 and MDA-MB-435 human cancer cells in a dose-dependent manner from 0.1 to 100 µM, without altering MMP-9 expression or proteolytic activity in HT-1080 cells. In addition, it attenuates both primary tumor growth and metastasis in vivo in a mouse model without obvious toxicity (20 mg/kg, 6 days/week, i.v. and i.t.). 产品目录编号 444293 品牌系列 Calbiochem®
同义词 MMP-9 PEX Inhibitor 参考 参考 Dufour, A., et al. 2011. Cancer Res. 71, 4977. 产品信息 形式 Yellow-white solid Hill配方 C₁₆H₁₇F₂N₃O₃S 化学配方 C₁₆H₁₇F₂N₃O₃S Molar Mass 369.39 结构配方图像 生物信息 纯度 ≥98% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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