merck millipore,默克密理愽
  • merck millipore,默克密理博,444291,MMP-12 Inhibitor, MMP408 - CAS 1258003-93-8 - Calbiochem

  • merck millipore,默克密理博,444291,MMP-12 Inhibitor, MMP408 - CAS 1258003-93-8 - Calbiochem

    产品名称：MMP-12 Inhibitor, MMP408 - CAS 1258003-93-8 - Calbiochem
    产品型号：444291
    The MMP-12 Inhibitor, MMP408, also referenced under CAS 1258003-93-8, controls the biological activity of MMP-12. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

    merck millipore,默克密理博,444291,MMP-12 Inhibitor, MMP408 - CAS 1258003-93-8 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,444291,MMP-12 Inhibitor, MMP408 - CAS 1258003-93-8 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₉H₂₀N₂O₇S1258003-93-8
    描述
    概述 A dibenzofuranylsulfanamido-valine compound that acts as a potent, active site zinc-targeting, MMP-12-selective inhibitor (IC50 = 2 nM against human MMP-12) with much weaker activity against MMP-12 from mouse/rat/sheep species (IC50 = 160, 320 and 22.3 nM , respectively) or human MMP-3/13/14 (IC50 = 351, 120 and 1100 nM , respectively), and practically ineffective toward human Agg-1/2 (IC50 >5 µM), TACE (IC50 >25 µM), and MMP-1/7 (IC50 >6 µM). MMP408 is orally active in mice and shown to effectively alleviate rhMMP-12-induced pulmonary inflammatory response in mice in vivo by more than 50% (5 mg/kg, p.o., b.i.d.).
    产品目录编号 444291
    品牌系列 Calbiochem®
    同义词 (S)-2-(8-(Methoxycarbonylamino)dibenzo[b,d]furan-3-sulfonamido)-3-methylbutanoic acid
    参考
    参考 Li, W., et al. 2009. J. Med. Chem. 52, 1799.
    产品信息
    CAS号 1258003-93-8
    形式 Off-white solid
    Hill配方 C₁₉H₂₀N₂O₇S
    化学配方 C₁₉H₂₀N₂O₇S
    Molar Mass 420.4
    结构配方图像
    生物信息
    纯度 ≥94% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,444291,MMP-12 Inhibitor, MMP408 - CAS 1258003-93-8 - Calbiochem

上一件merck millipore产品：merck millipore,默克密理博,613424,Tocopherol Set - Calbiochem
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