merck millipore,默克密理愽
  • merck millipore,默克密理博,444145,MDM2 Inhibitor - CAS 562823-84-1 - Calbiochem

  • merck millipore,默克密理博,444145,MDM2 Inhibitor - CAS 562823-84-1 - Calbiochem

    产品名称：MDM2 Inhibitor - CAS 562823-84-1 - Calbiochem
    产品型号：444145
    The MDM2 Inhibitor, also referenced under CAS 562823-84-1, controls the biological activity of MDM2.

    merck millipore,默克密理博,444145,MDM2 Inhibitor - CAS 562823-84-1 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,444145,MDM2 Inhibitor - CAS 562823-84-1 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₅H₁₂BIO₃562823-84-1
    描述
    概述 A cell-permeable boranyl-chalcone that binds strongly to MDM2 and irreversibly disrupts MDM2/p53 protein complex. Exhibits selective toxicity towards MDM2 overexpressing human breast cancer cell lines (IC50 = 10, 8.8, and 7 µM for MDA-MB-435, MDA-MB-231, and Wt-MCF7, respectively) compared to normal breast cell lines (IC50 = 75 and 63 µM for MCF-10A and MCF-12A, respectively).
    产品目录编号 444145
    品牌系列 Calbiochem®
    同义词 trans-4-Iodo, 4ʹ-boranyl-chalcone, MDM2 Antagonist IV
    参考
    参考 Kumar, S.K., et al. 2003. J. Med. Chem. 46, 2813.
    产品信息
    CAS号 562823-84-1
    具有ATP竞争性 N
    形式 Pale yellow solid
    Hill配方 C₁₅H₁₂BIO₃
    化学配方 C₁₅H₁₂BIO₃
    Molar Mass 378.0
    可逆 N
    结构配方图像
    生物信息
    主靶 MDM2
    主靶IC50 10, 8.8, and 7 µM in selective toxicity for MDA-MB-435, MDA-MB-231, and Wt-MCF7, respectively
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Carcinogenic / Teratogenic
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,444145,MDM2 Inhibitor - CAS 562823-84-1 - Calbiochem

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下一件merck millipore产品：merck millipore,默克密理博,CB1040,Anti-S100B Mouse mAb (1B2)


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