merck millipore,默克密理愽
  • merck millipore,默克密理博,420640,Ketohexokinase Inhibitor - Calbiochem

  • merck millipore,默克密理博,420640,Ketohexokinase Inhibitor - Calbiochem

    产品名称：Ketohexokinase Inhibitor - Calbiochem
    产品型号：420640


    merck millipore,默克密理博,420640,Ketohexokinase Inhibitor - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,420640,Ketohexokinase Inhibitor - Calbiochem

    重要规格表

    经验配方
    C₂₁H₂₆N₈S•2HCl
    描述
    概述 An orally bioavailable pyrimidinopyrimidine compound that acts as a potent, reversible and ATP-competitive inhibitor of human hepatic KHK activity (KHK-C isoform; IC50 = 12 nM in a transcreener ADP assay) and efficiently blocks fructose-1-phosphate secretion (IC50 ≤ 400 nM in HepG2 cells). Displays ~50-fold lower potency towards metabolic kinases, namely, ribokinase, hexokinase and adenosine kinase, and minimal binding affinities to diverse receptors and ion-channels, and excellent selectivity among a panel of 31-kinases including Akt1, AMPK, CaMKI/II, InsR, IRAK4, PKA and PKCθ (IC50 >> 10 µM). Shown to minimally affect the activities of human cytochrome p450 isozymes (1A2, 2C19, 2D6, 2C9 and 3A4), and exhibit high volume of distribution and high rate of clearance in rats.
    产品目录编号 420640
    品牌系列 Calbiochem®
    同义词 N⁸-(Cyclopropylmethyl)-N⁴-(2-(methylthio)phenyl)-2-(1-piperazinyl)-pyrimido[5,4-d]pyrimidine-4,8-diamine, KHK Inhibitor
    参考
    参考 Maryanoff, B.E., et al. 2011. ACS Med. Chem. Lett. 2, 538.
    产品信息
    形式 Yellow solid
    Hill配方 C₂₁H₂₆N₈S•2HCl
    化学配方 C₂₁H₂₆N₈S•2HCl
    Molar Mass 495.5
    结构配方图像
    生物信息
    纯度 ≥97% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,420640,Ketohexokinase Inhibitor - Calbiochem

上一件merck millipore产品：merck millipore,默克密理博,200100,Benzyl-2-acetamido-2-deoxy-α-D-galactopyranoside - CAS 3554-93-6 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,DPP4,DPP IV Inhibitor


相关产品

merck millipore,默克密理博,12-359,Acetyl-Histone H3 (Lys14) Peptide merck millipore,默克密理博,12-359,Acetyl-Histone H3 (Lys14) Peptide

merck millipore,默克密理博,MAB1510,Anti-Ubiquitin Antibody, clone Ubi-1 (aka 042691GS) merck millipore,默克密理博,MAB1510,Anti-Ubiquitin Antibody, clone Ubi-1 (aka 042691GS)

merck millipore,默克密理博,MABF83,Anti-CD2 Antibody, clone RPA-2.10 merck millipore,默克密理博,MABF83,Anti-CD2 Antibody, clone RPA-2.10

merck millipore,默克密理博,ABT349,Anti-EFS Antibody merck millipore,默克密理博,ABT349,Anti-EFS Antibody

merck millipore,默克密理博,200100,Benzyl-2-acetamido-2-deoxy-α-D-galactopyranoside - CAS 3554-93-6 - Calbiochem merck millipore,默克密理博,200100,Benzyl-2-acetamido-2-deoxy-α-D-galactopyranoside - CAS 3554-93-6 - Calbioc...

merck millipore,默克密理博,DPP4,DPP IV Inhibitor merck millipore,默克密理博,DPP4,DPP IV Inhibitor

merck millipore,默克密理博,SCR601,Human Oligodendrocyte Characterization Kit merck millipore,默克密理博,SCR601,Human Oligodendrocyte Characterization Kit

merck millipore,默克密理博,CYT298,C-Reactive Protein ELISA Kit, Human merck millipore,默克密理博,CYT298,C-Reactive Protein ELISA Kit, Human

merck millipore,默克密理博,CC1023,Human Integrin αVβ5, Octyl-β-D-glucopyranoside Formulation merck millipore,默克密理博,CC1023,Human Integrin αVβ5, Octyl-β-D-glucopyranoside Formulation

merck millipore,默克密理博,HTS103M,ChemiSCREEN™ Human D3 Dopamine Receptor Membrane Preparation merck millipore,默克密理博,HTS103M,ChemiSCREEN™ Human D3 Dopamine Receptor Membrane Preparation


whatman,沃特曼,nalgene,耐洁,merck millipore,默克密理愽,sartorius,赛多利斯,pall,颇尔
thermo fisher,赛默飞世尔,GE,MN,macherey-nagel,advantec,wheaton,brand,普兰德,welch,airtech


上海羽令过滤器材有限公司版权所有 Copyright ©  www.yl-guolv.com  Powered by 羽令集团—信息技术部