merck millipore,默克密理愽
  • merck millipore,默克密理博,420358,CBFβ Activator, Kartogenin - Calbiochem

  • merck millipore,默克密理博,420358,CBFβ Activator, Kartogenin - Calbiochem

    产品名称：CBFβ Activator, Kartogenin - Calbiochem
    产品型号：420358
    The CBFβ Activator, Kartogenin modulates the biological activity of CBFβ. This small molecule/inhibitor is primarily used for Biochemicals applications.

    merck millipore,默克密理博,420358,CBFβ Activator, Kartogenin - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,420358,CBFβ Activator, Kartogenin - Calbiochem

    重要规格表

    经验配方
    C₂₀H₁₅NO₃
    描述
    概述 A cell-permeable biphenylcarbamoylbenzoate compound that potently induces the differentiation of human mesenchymal stem cells (hMSCs) into chondrocytes (EC50 = 100 nM). Reversibly binds to the FC-1 fragment of filamin A and disrupts its association with CBFβ leading to nuclear localization of CBFβ and binding to runt-related transcription factor (RUNX) to regulate chondrogenesis. Also reported to inhibit cytokine-induced release of nitric oxide (NO) and glycosaminoglycan (GAG). Exhibits chondroprotective properties and promotes cartilage repair in murine osteoarthritis models. Shown to up-regulate the levels of TIMP1, collagen, and aggrecan thereby blocking further matrix breakdown without affecting the activities of MMP-3, MMP-13, and aggrecanase in primary chondrocytes or hMSCs.
    产品目录编号 420358
    品牌系列 Calbiochem®
    同义词 2-(Biphenyl-4-ylcarbamoyl)benzoic acid
    参考
    参考 Johnson, K., et al. 2012. Science 336, 717.
    产品信息
    形式 White solid
    Hill配方 C₂₀H₁₅NO₃
    化学配方 C₂₀H₁₅NO₃
    Molar Mass 317.3
    结构配方图像
    生物信息
    纯度 ≥99% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,420358,CBFβ Activator, Kartogenin - Calbiochem

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