merck millipore,默克密理愽
  • merck millipore,默克密理博,200275,Berberine Chloride - CAS 633-65-8 - Calbiochem

  • merck millipore,默克密理博,200275,Berberine Chloride - CAS 633-65-8 - Calbiochem

    产品名称：Berberine Chloride - CAS 633-65-8 - Calbiochem
    产品型号：200275
    A highly potent and selective oxysterol EBI2 (GPR183) agonist (Kd) = 450 pM in a saturation binding assay, and EC₅₀ = 140 pM over EC₅₀ = 2.1 nM for its enantiomer, 7β,25-OHC, in a GTP-γS bi More>>

    merck millipore,默克密理博,200275,Berberine Chloride - CAS 633-65-8 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,200275,Berberine Chloride - CAS 633-65-8 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₀H₁₈NO₄+Cl-633-65-8
    描述
    概述 A highly potent and selective oxysterol EBI2 (GPR183) agonist (Kd) = 450 pM in a saturation binding assay, and EC50 = 140 pM over EC50 = 2.1 nM for its enantiomer, 7β,25-OHC, in a GTP-γS binding assay). Dose-dependently suppresses forskolin-induced cAMP accumulation in an EBI2-expressing SK-N-MC/CRE-β-galactosidase cell line (IC50 = 2 nM), but not in control cells. Stimulates migration of LPS-activated spleen B-cells and anti-CD3/CD28-activated CD4+ T-cells in a dose-dependent manner. In addition, pharmacological inhibition of its biosynthesis in vivo by Clotrimazole, a CYP7B1inhibitor, promotes the migration of adoptively transferred pre-activated B cells to the T/B boundary, mimicking the phenotype of pre-activated B cells in EBI2-deficient mice.
    产品目录编号 200275
    品牌系列 Calbiochem®
    同义词 Berberine
    参考
    参考 Kinm. B., et al. 2011, Brit. Journ. Pharm.164, 106.
    Kong, W., et al. 2004, Nature Med. 10, 1344.
    Dimlich, R. et al. 1980, Stain Technol. 55, 217.
    产品信息
    CAS号 633-65-8
    形式 Yellow powder
    Hill配方 C₂₀H₁₈NO₄+Cl-
    化学配方 C₂₀H₁₈NO₄+Cl-
    Molar Mass 371.81
    结构配方图像
    生物信息
    纯度 ≥95% by HPLC (NMR if no UV signal)
    理化信息
    溶解度 DMSO or H₂O
    储存和货运信息
    货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,200275,Berberine Chloride - CAS 633-65-8 - Calbiochem

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