• merck millipore,默克密理博,AB1586,Anti-Ubiquitin Antibody
  • merck millipore,默克密理博,AB1586,Anti-Ubiquitin Antibody

    产品名称:Anti-Ubiquitin Antibody
    产品型号:AB1586
    Detect Ubiquitin using this Anti-Ubiquitin Antibody validated for use in WB, IH.

    merck millipore,默克密理博,AB1586,Anti-Ubiquitin Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB1586,Anti-Ubiquitin Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Sh, Eu, H, RbIHC, WBShSerumPolyclonal Antibody
    描述
    产品目录编号 AB1586
    Replaces 04-454
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Ubiquitin Antibody
    产品信息
    格式 Serum
    演示 Sheep serum. Lyophilized, no preservatives. Reconstitute with 100 mL of sterile distilled water. Centrifuge to remove any residue.
    应用
    应用 Detect Ubiquitin using this Anti-Ubiquitin Antibody validated for use in WB, IH.
    主要应用
    • Immunohistochemistry
    • Western Blotting
    应用说明 Immunohistochemistry: 1:2,000-1:5,000.

    Immunoblotting: 1:1,000-1:2,000 (depending on detection system used).

    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 Ubiquitin from bovine red blood cells coupled to chicken gamma globulin.
    宿主 Sheep
    特异性 Recognizes both free ubiquitin and ubiquitin-protein conjugates on Western blots. Labels tangles and Lewy bodies in paraffin or frozen human brain sections.
    品种反应性 SheepEukaryoteHumanRabbit
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_021009.4
    Entrez基因汇总 This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin is required for ATP-dependent, nonlysosomal intracellular protein degradation of abnormal proteins and normal proteins with a rapid turnover. Ubiquitin is covalently bound to proteins to be degraded, and presumably labels these proteins for degradation. Ubiquitin also binds to histone H2A in actively transcribed regions but does not cause histone H2A degradation, suggesting that ubiquitin is also involved in regulation of gene expression. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. Aberrant form of this protein has been noticed in patients with Alzheimer's and Down syndrome.
    基因符号
    • UBCEP2
    • UBC
    • UBA80
    • HMG20
    • UBCEP1
    • Ubiquitin.
    • UBA52
    • UBB
    UniProt编号
    • P62988
    UniProt汇总 FUNCTION: SwissProt: P62988 # Protein modifier which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Attachment to proteins as a Lys-48-linked polymer usually leads to their degradation by proteasome. Attachment to proteins as a monomer or as an alternatively linked polymer does not lead to proteasomal degradation and may be required for numerous fonctions, including maintenance of chromatin structure, regulation of gene expression, stress response, ribosome biogenesis and DNA repair.
    SIZE: 76 amino acids; 8565 Da
    SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
    PTM: Several types of polymeric chains can be formed, depending on the lysine used for the assembly.
    SIMILARITY: SwissProt: P62988 ## Belongs to the ubiquitin family.
    MISCELLANEOUS: Ubiquitin is synthesized as a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains. In some species there is a final amino-acid after the last repeat, here in human a Val. Some ubiquitin genes contain a single copy of ubiquitin fused to a ribosomal protein (either L40 or S27a).
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -20 to -70°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles. Glycerol (1:1) can be added for additional stability.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,AB1586,Anti-Ubiquitin Antibody

上一件merck millipore产品:merck millipore,默克密理博,14-665,MSSK1 Protein, active, 10 µg
下一件merck millipore产品:merck millipore,默克密理博,14-674,EphB1 Protein, active, 10 µg



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