merck millipore,默克密理愽
  • merck millipore,默克密理博,420101,JAK3 Inhibitor I - CAS 202475-60-3 - Calbiochem

  • merck millipore,默克密理博,420101,JAK3 Inhibitor I - CAS 202475-60-3 - Calbiochem

    产品名称：JAK3 Inhibitor I - CAS 202475-60-3 - Calbiochem
    产品型号：420101
    The JAK3 Inhibitor I, also referenced under CAS 202475-60-3, controls the biological activity of JAK3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applicati More>>

    merck millipore,默克密理博,420101,JAK3 Inhibitor I - CAS 202475-60-3 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,420101,JAK3 Inhibitor I - CAS 202475-60-3 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₆H₁₅N₃O₃202475-60-3
    描述
    概述 A cell-permeable, reversible, potent, ATP-competitive, and specific inhibitor of JAK3 (Janus family kinase 3; IC50 = 78 µM). Has no effect on JAK1, JAK2, or Zap/Syk or Src tyrosine kinases. Acts as a potent inhibitor of glioblastoma cell adhesion and migration. Also reported to block thrombin-induced platelet aggregation.
    产品目录编号 420101
    品牌系列 Calbiochem®
    同义词 4-(4ʹ-Hydroxyphenyl)amino-6,7-dimethoxyquinazoline, WHI-P131
    参考
    参考 Tibbles, H.E., et al. 2001. J. Biol. Chem. 276, 17815.
    Sudbeck, E.A., et al. 1999. Clin. Cancer Res. 5, 1569.
    Goodman, P.A., et al. 1998. J. Biol. Chem. 273, 17742.
    Narla, R.K., et al. 1998. Clin. Cancer Res. 4, 2463.
    产品信息
    CAS号 202475-60-3
    具有ATP竞争性 Y
    形式 White to off-white solid
    Hill配方 C₁₆H₁₅N₃O₃
    化学配方 C₁₆H₁₅N₃O₃
    Molar Mass 297.3
    可逆 Y
    结构配方图像
    生物信息
    主靶 Janus family kinase 3
    主靶IC50 78 µM against Janus family kinase 3
    纯度 ≥97% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,420101,JAK3 Inhibitor I - CAS 202475-60-3 - Calbiochem

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