merck millipore,默克密理博,419825,Hh Signaling Antagonist X, Itraconazole - CAS 84625-61-6

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Merck Millipore 默克密理愽

merck millipore,默克密理博,419825,Hh Signaling Antagonist X, Itraconazole - CAS 84625-61-6 - Calbiochem

经验配方	CAS号
C₃₅H₃₈Cl₂N₈O₄	84625-61-6

描述
概述	A cell-permeable, orally available triazole-class antifungal agent that, in addition to its known inhibitory activity against fungal cytochrome P450 14-α-demethylase, also acts as an effective Hh signaling inhibitor (IC₅₀ ~ 0.8 µM against SHHN-induced Gli transcription activity in Shh-Light2 cells) in a Ptch-independent manner (IC₅₀ ~ 0.9 µM against Ptch promoter-mediated transcription activity in murine Ptch^-/- fibroblasts), presumably by binding smoothened (smo) at a site distinct from that targeted by cyclopamine (Cat. No. 239803) and SAG (Cat. No. 566660), as Itraconazole does not compete with BODIPY-cyclopamine binding, and it alters only the magnitude, but not the EC₅₀, of SAG-induced Gli transcription activity in Shh-Light2 cells. Shown to effectively suppress Hh pathway-dependent growth of both engrafted medulloblastoma and endogenous basal cell carcinoma in mice in vivo (37.5 to 100 mg/kg/12 hr, p.o.) in a reversible manner.
产品目录编号	419825
品牌系列	Calbiochem®
同义词	14LDM Inhibitor, Oriconazole, R51211, Smo Antagonist VII, Sporanox, 14-α-demethylase Inhibitor

参考
参考	Kim, J., et al. 2010. Cancer Cell 17, 388.

生物信息
纯度	≥98% by HPLC

理化信息
溶解度	DMSO

安全信息
R相	R: 20/21/22 Harmful by inhalation, in contact with skin and if swallowed.

储存和货运信息
货运代码	Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性	Harmful
储存	+2°C to +8°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstituiton, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

包装信息
惰性气体下包装	Packaged under inert gas

merck millipore,默克密理博,419825,Hh Signaling Antagonist X, Itraconazole - CAS 84625-61-6 - Calbiochem

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