merck millipore,默克密理博,410957,3-Isobutyl-1-methylxanthine - CAS 28822-58-4

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merck millipore,默克密理博,410957,3-Isobutyl-1-methylxanthine - CAS 28822-58-4 - Calbiochem
产品名称：3-Isobutyl-1-methylxanthine - CAS 28822-58-4 - Calbiochem
产品型号：410957
A cell-permeable, non-specific inhibitor of cAMP and cGMP phosphodiesterases (IC₅₀ = 2-50 µM).

merck millipore,默克密理博,410957,3-Isobutyl-1-methylxanthine - CAS 28822-58-4 - Calbiochem

产品介绍

merck millipore,默克密理博,410957,3-Isobutyl-1-methylxanthine - CAS 28822-58-4 - Calbiochem

重要规格表

经验配方	CAS号
C₁₀H₁₄N₄O₂	28822-58-4

描述
概述	A cell-permeable, non-specific inhibitor of cAMP and cGMP phosphodiesterases (IC₅₀ = 2-50 µM). Also acts as an adenosine receptor antagonist. Reported to inhibit TNF-α expression in adipocyte precursor cells.
产品目录编号	410957
品牌系列	Calbiochem®
同义词	IBMX

参考
参考	Hube, F., et al. 1999. Horm. Metab. Res. 31, 359. Morgan, A.J., et al. 1993. Biochem. Pharmacol. 45, 2373. Scamps, F., et al. 1993. Eur. J. Pharmacol. 244, 119. Turner, N.C., et al. 1993. Br. J. Pharmacol. 108, 876. Tamura, T., et al. 1991. J. Gen. Physiol. 98, 95. Beavo, J.A., and Reifsnyder, D.H. 1990. Trends Pharmacol. Sci. 11, 150. Russell, T.R. 1979. Proc. Natl. Acad. Sci. USA 76, 4451.

参考

Hube, F., et al. 1999. Horm. Metab. Res. 31, 359.
Morgan, A.J., et al. 1993. Biochem. Pharmacol. 45, 2373.
Scamps, F., et al. 1993. Eur. J. Pharmacol. 244, 119.
Turner, N.C., et al. 1993. Br. J. Pharmacol. 108, 876.
Tamura, T., et al. 1991. J. Gen. Physiol. 98, 95.
Beavo, J.A., and Reifsnyder, D.H. 1990. Trends Pharmacol. Sci. 11, 150.
Russell, T.R. 1979. Proc. Natl. Acad. Sci. USA 76, 4451.

产品信息
CAS号	28822-58-4
具有ATP竞争性	N
形式	White solid
Hill配方	C₁₀H₁₄N₄O₂
化学配方	C₁₀H₁₄N₄O₂
Molar Mass	222.2
可逆	N
结构配方图像

生物信息
主靶	cAMP and cGMP phosphodiesterases
主靶IC₅₀	2-50 µM against cAMP and cGMP phosphodiesterases
纯度	≥98% by HPLC

理化信息
细胞可渗透	Y
溶解度	DMSO, EtOH, or MeOH

GHS安全信息
RTECS	ZD8500000

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	-20°C
无需冷冻	No
特殊指南	Following reconstitution in ethanol or methanol, refrigerate (4°C). Following reconstitution in DMSO, aliquot and freeze (-20°C). Ethanol/methanol and DMSO stock solutions are stable for up to 6 months at 4°C or -20°C, respectively.