merck millipore,默克密理愽
  • merck millipore,默克密理博,475957,c-Myc Inhibitor II - CAS 413611-93-5 - Calbiochem

  • merck millipore,默克密理博,475957,c-Myc Inhibitor II - CAS 413611-93-5 - Calbiochem

    产品名称：c-Myc Inhibitor II - CAS 413611-93-5 - Calbiochem
    产品型号：475957
    The c-Myc Inhibitor II, also referenced under CAS 413611-93-5, controls the biological activity of c-Myc.

    merck millipore,默克密理博,475957,c-Myc Inhibitor II - CAS 413611-93-5 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,475957,c-Myc Inhibitor II - CAS 413611-93-5 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₈H₁₂N₄O₃413611-93-5
    描述
    概述 A cell-permeable benzoxadiazole compound that is shown to preferentially disrupt the interactions of c-Myc-Max, Mad1-Max, and Myf5-HEB, over those of 31 other pairs of HLH-, ZIP-, and HLH-ZIP-containing proteins. Similarly to 10058-F4 (Cat. No. 475956), 10074-G5 is shown to selectively inhibit the c-Myc-dependent growth of rat fibroblast cell line TGR1 and effectively suppress c-Myc-dependent transcription activity. Binding studies using various mutated and truncated c-Myc constructs reveal that 10074-G5 targets c-Myc helix-1 region between aa residues 363 and 381 (KD = 4.4 µM), while 10058-F4 interaction site is located within aa residues 402 through 412 (KD = 13 µM).
    产品目录编号 475957
    品牌系列 Calbiochem®
    同义词 7-Nitro-N-(2-phenylphenyl)-2,1,3-benzoxadiazol-4-amine, Biphenyl-2-yl-(7-nitrobenzo[1,2,5]oxadiazol-4-ylamine, 10074-G5
    参考
    参考 Follis, A.V., et al. 2008. Chem. Biol. 15, 1149.
    Yin, X., et al. 2003. Oncogene 22, 6151.

    Sold under license of U.S. Patent 7,026,343.
    产品信息
    CAS号 413611-93-5
    形式 Deep orange solid
    Hill配方 C₁₈H₁₂N₄O₃
    化学配方 C₁₈H₁₂N₄O₃
    Molar Mass 332.3
    生物信息
    纯度 ≥95% by HPLC
    理化信息
    溶解度 DMSO or EtOH
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,475957,c-Myc Inhibitor II - CAS 413611-93-5 - Calbiochem

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