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经验配方 C₃₀H₅₁N₁₂O₉₃· 3TFA 描述 概述 A cell-permeable, hexapeptide containing a novel integrin-binding motif, SDV (a Type I PDZ-binding motif) that is shown to compete with vitronectin for the RGD-binding site of integrin αvβ3 (IC50 = 1.74 pg/ml), in a chip-based assay. It is rapidly internalized into HUVECs, but not in NIH 3T3 cells, at a culture temperature of 37 °C, a process which is mediated by caveolin and clathrin. At 10 µg/ml, this compound is shown to significantly inhibit the phosphorylation of ERK1/2 and MEK in HUVECs. Furthermore, it suppresses bFGF-induced proliferation of HUVECs, dose-dependently, and displays up-regulation of p53 and induction of apoptosis via activation of caspases-3, -8 and -9 at 50 µg/ml. 产品目录编号 407272 品牌系列 Calbiochem®
同义词 HSDVHK-NH2, HSDVHK 参考 参考 Bang, J., et al. 2011. Mol Cell Proteomics 10, M110.
Choi, Y., et al. 2010. Proteomics 10, 72.
Lee, Y., et al. 2004. J. Biomol. Screen. 9, 687.产品信息 形式 White solid 配方 Supplied as a trifluoracetate salt. Hill配方 C₃₀H₅₁N₁₂O₉₃· 3TFA 化学配方 C₃₀H₅₁N₁₂O₉₃· 3TFA Molar Mass 1062.9 结构配方图像 生物信息 纯度 ≥95% by HPLC 理化信息 溶解度 H₂O 储存和货运信息 货运代码 Shipped with Blue Ice or with Dry Ice
毒性 Standard Handling
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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