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  • merck millipore,默克密理博,ABC32,Anti-Atg4B Antibody

  • merck millipore,默克密理博,ABC32,Anti-Atg4B Antibody

    产品名称：Anti-Atg4B Antibody
    产品型号：ABC32
    Anti-Atg4B detects levels of Atg4B proteins & has been published & validated for use in WB.

    merck millipore,默克密理博,ABC32,Anti-Atg4B Antibody

  • 产品介绍
  • merck millipore,默克密理博,ABC32,Anti-Atg4B Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 ABC32
    描述 Anti-Atg4B Antibody
    Alternate Names
    • hAPG4B
    • Cysteine protease ATG4B
    • AUT-like 1 cysteine endopeptidase
    • Autophagin-1
    • Autophagy-related cysteine endopeptidase 1<br />Autophagy-related protein 4 homolog B
    背景信息 Atg4B (autophagy-related protein 4B) is a member of the Atg4 family of C54 endopeptidases that are required for the synthesis of autophagosomes. Atg4B serves as a cysteine-protease that is essential for LC3 lipidation during autophagosome formation and also for de-lipidation during autophagosome recycling.
    产品信息
    格式 Affinity Purified
    控制
    • HeLa cell lysate
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Anti-Atg4B detects levels of Atg4B proteins & has been published & validated for use in WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to the human Atg4B.
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    品种反应性 MouseHuman
    Species Reactivity Note Demonstrated to react with Human.
    Predicted to react with Mouse based on 100% sequence homology. Other homologies: Rat (80% sequence homology).
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_037457
    Entrez基因汇总 Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
    基因符号
    • AUTL1
    • ATG4B
    • APG4B
    纯化方法 Affinity Purified
    UniProt编号
    • Q9Y4P1
    UniProt汇总 FUNCTION: Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes.

    ENZYME REGULATION: Inhibited by N-ethylmaleimide.

    SUBCELLULAR LOCATION: Cytoplasm.

    TISSUE SPECIFICITY: Mainly expressed in the skeletal muscle, followed by brain, heart, liver and pancreas.
    产品使用声明
    质量保证 Evaluated by Western Blot in HeLa cell lysate.

    Western Blot Analysis: 0.5 µg/mL of this antibody detected Atg4B in 10 µg of HeLa cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,ABC32,Anti-Atg4B Antibody

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