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经验配方 CAS号 C₁₉H₁₆ClNO₄ 53-86-1 描述 概述 A non-steroidal anti-inflammatory, cell permeable, antipyretic agent. Non-selective COX inhibitor (IC50 = 740 nM for COX-1; IC50 = 970 nM for COX-2). Inhibits phospholipase A2 (IC50 = 145 µM). Strongly inhibits insoluble transthyretin (TTR) amyloid fibril formation and suppresses production of Aβ-peptide and secreted form of APP by inhibition of APP mRNA levels in NG108-15 cells. 产品目录编号 405268 品牌系列 Calbiochem®
同义词 1-(p-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic Acid 参考 参考 Kodoyama, K., et al. 2001. Biochem. Biophys. Res. Commun. 281, 483.
Weggen, S., et al. 2001. Nature 414, 212.
Kalgutkar, A.S., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 925.
Klabunde, T., et al. 2000. Nat. Struct. Biol. 7, 312.
Futaki, N., et al. 1994. Prostaglandins 47, 55.
Futaki, N., et al. 1994. Prostaglandins 47, 55.
Stevenson, K.M., and Lumbers, E.R. 1992. J. Dev. Physiol. 17, 257.
Oliw, E. 1980. Prostaglandins 19, 271.产品信息 CAS号 53-86-1 具有ATP竞争性 N 形式 White to off-white powder Hill配方 C₁₉H₁₆ClNO₄ 化学配方 C₁₉H₁₆ClNO₄ Molar Mass 357.8 可逆 N 结构配方图像 生物信息 主靶 COX-1 主靶IC50 740 nM 纯度 ≥98% by assay 理化信息 细胞可渗透 Y 溶解度 EtOH GHS安全信息 RTECS NL3500000 安全信息 R相 R: 28-42/43-63
Very toxic if swallowed.
May cause sensitization by inhalation and skin contact.
Possible risk of harm to the unborn child.S相 S: 36/37/39-45
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).储存和货运信息 货运代码 Ambient Temperature Only
毒性 Highly Toxic & Carcinogenic / Teratogenic
有害材料注意事项： Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
储存 +15°C to +30°C
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
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