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merck millipore,默克密理博,400093,HIF-PHD Inhibitor II, JNJ-42041935 - Calbiochem
产品名称：HIF-PHD Inhibitor II, JNJ-42041935 - Calbiochem
产品型号：400093
The HIF-PHD Inhibitor II, JNJ-42041935 controls the biological activity of HIF-PHD. This small molecule/inhibitor is primarily used for Cell Structure applications.
merck millipore,默克密理博,400093,HIF-PHD Inhibitor II, JNJ-42041935 - Calbiochem
- 产品介绍
重要规格表
经验配方 C₁₂H₆ClF₃N₄O₃ 描述 概述 A cell-permeable benzimidazolopyrazole compound that acts as an active-site binding, iron insensitive, 2-oxoglutarate competitive, reversible and potent inhibitor of PHD1, 2 and 3 isozymes (pKi = 7.91, 7.29 and 7.65, respectively). Displays >100-fold selectivity over FIH (factor inhibiting hydroxylase; pIC50 ~ 4) and minimal affinity towards a panel of receptors, enzymes and kinases. Shown to elevate HIF-1α levels in Hep3B cells and stimulate erythropoietin secretion in mice, and reverse inflammation-induced anemia in rats (100 µM/kg). Shown to inhibit malate dehydrogenase 2 (MDH2) activity and suppress mitochondrial respiration. 产品目录编号 400093 品牌系列 Calbiochem®
同义词 1-(5-Chloro-6-(trifluoromethoxy)-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid, HIF Prolyl Hydroxylase Inhibitor II 参考 参考 Lee, K., et al., 2013. Angew. Chem. Int. Ed. 52, In press.
Barrett, T.D., et al. 2011. Mol. Pharmacol. 79, 910.
Rosen, M.D., et al. 2010. ACS Med. Chem. Lett. 1, 526.产品信息 形式 White solid Hill配方 C₁₂H₆ClF₃N₄O₃ 化学配方 C₁₂H₆ClF₃N₄O₃ Molar Mass 346.7 结构配方图像 生物信息 纯度 ≥99% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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