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merck millipore,默克密理博,373403,InSolution™ Hh/Gli Antagonist, GANT61 - CAS 500579-04-4 - Calbiochem
产品名称：InSolution™ Hh/Gli Antagonist, GANT61 - CAS 500579-04-4 - Calbiochem
产品型号：373403
The InSolution™ Hh/Gli Antagonist, GANT61, also referenced under CAS 500579-04-4, controls the biological activity of Hh/Gli. This small molecule/inhibitor is primarily used for Cell Signaling applica More>>
merck millipore,默克密理博,373403,InSolution™ Hh/Gli Antagonist, GANT61 - CAS 500579-04-4 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₂₇H₃₅N₅ 500579-04-4 描述 概述 A cell-permeable hexahydropyrimidine compound that displays similar pharmacological property as, but is structurally disctinct from, GANT58 (Cat. No. 373400). While both compounds act as downstream Hedgehog (Hh) pathway-selective blockers and target Gli-mediated gene transactivation with similar potency (IC50 ~5 µM) in SAG-stimulated Shh-L2 cells, GANT61 does exhibit better in vivo antitumor efficacy, presumably due to its superior pharmacokinetics, and only GANT61, but not GANT58, is shown to inhibit Gli DNA binding in HEK293 cells. The solid form of this compound (Cat. No. 373401) is also available. 产品目录编号 373403 品牌系列 Calbiochem®
同义词 2-((3-(2-(Dimethylamino)benzyl)-2-(4-pyridinyl)tetrahydro-1(2H)-pyrimidinyl)methyl)-N,N-dimethylaniline, 2,2ʹ-(2-(Pyridin-4-yl)dihydropyrimidine-1,3(2H,4H)-diyl)bis(methylene)bis(N,N-dimethylaniline), NSC 136476 参考 参考 Lauth, M., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 8455. 产品信息 CAS号 500579-04-4 形式 Liquid 配方 A 25 mM (2 mg/186 µL) solution of Hh/Gli Antagonist, GANT61 (Cat. No. 373401) in DMSO. Hill配方 C₂₇H₃₅N₅ Molar Mass 429.6 吸湿 Hygroscopic
结构配方图像 生物信息 主靶 Gli1 and Gli2 纯度 ≥95% by HPLC 理化信息 细胞可渗透 Y 安全信息 R相 R: 36/38
Irritating to eyes and skin.S相 S: 26-36
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.储存和货运信息 货运代码 Dry Ice Only
毒性 Irritant
储存 -20°C
避光 Protect from light
吸湿 Hygroscopic
避免冻结 / 解冻 Avoid freeze/thaw
无需冷冻 No
特殊指南 Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 1 year at -70°C. 包装信息 惰性气体下包装 Packaged under inert gas
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