merck millipore,默克密理博,393204,4-Hydroxynonenal - CAS 75899-68-2

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merck millipore,默克密理博,393204,4-Hydroxynonenal - CAS 75899-68-2 - Calbiochem
产品名称：4-Hydroxynonenal - CAS 75899-68-2 - Calbiochem
产品型号：393204
A major aldehyde product formed by peroxidation of ω-6-unsaturated fatty acids that is regarded as a specific marker of lipid peroxidation.

merck millipore,默克密理博,393204,4-Hydroxynonenal - CAS 75899-68-2 - Calbiochem

产品介绍

merck millipore,默克密理博,393204,4-Hydroxynonenal - CAS 75899-68-2 - Calbiochem

重要规格表

经验配方	CAS号
C₉H₁₆O₂	75899-68-2

描述
概述	A major aldehyde product formed by peroxidation of ω-6-unsaturated fatty acids that is regarded as a specific marker of lipid peroxidation. Inhibits proliferation and induces differentiation of HL-60 human leukemic cells. Also induces cell death in murine alveolar macrophages and in PC12 cells. An inhibitor of state 3 respiration at micromolar levels. Causes a transient increase in cytosolic Ca²⁺ and irreversibly inhibits Na⁺, K⁺-ATPase activity (IC₅₀ = 120 µM). Acts as a reversible inhibitor of c-Jun N-terminal kinase (JNK).
产品目录编号	393204
品牌系列	Calbiochem®
同义词	HNE, 4-Hydroxy-2-nonenal

参考
参考	Soh, Y., et al. 2000. Mol. Pharmacol. 58, 535. Carini, R., et al. 1996. Biochem. Biophys. Res. Commun. 218, 772. Li, L., et al. 1996. Toxicol. Appl. Pharmacol. 139, 135. Siems, W.G., et al. 1996. Free Radic. Res. 20, 215. Ullrich, O., et al. 1996. Free Radic. Res. 24, 421. van Kuijk, F.J., et al. 1995. Anal. Biochem. 224, 420. Esterbauer, H., et al. 1991. Free Radic. Biol. Med. 11, 81.

参考

Soh, Y., et al. 2000. Mol. Pharmacol. 58, 535.
Carini, R., et al. 1996. Biochem. Biophys. Res. Commun. 218, 772.
Li, L., et al. 1996. Toxicol. Appl. Pharmacol. 139, 135.
Siems, W.G., et al. 1996. Free Radic. Res. 20, 215.
Ullrich, O., et al. 1996. Free Radic. Res. 24, 421.
van Kuijk, F.J., et al. 1995. Anal. Biochem. 224, 420.
Esterbauer, H., et al. 1991. Free Radic. Biol. Med. 11, 81.

产品信息
CAS号	75899-68-2
具有ATP竞争性	N
形式	Liquid
配方	Supplied at 10 mg/ml in ethanol
Hill配方	C₉H₁₆O₂
化学配方	C₉H₁₆O₂
Molar Mass	156.2
可逆	N
结构配方图像

生物信息
主靶	Na⁺, K⁺-ATPase activity
主靶IC₅₀	120 µM against Na⁺, K⁺-ATPase activity
纯度	≥98% by HPLC

理化信息
细胞可渗透	N

GHS安全信息
RTECS	RA8510000

安全信息
R相	R: 11 Highly flammable.
S相	S: 7-16 Keep container tightly closed. Keep away from sources of ignition - No Smoking.

储存和货运信息
货运代码	Dry Ice Only
毒性	Flammable
有害材料注意事项：	Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
储存	≤ -70°C
无需冷冻	No
特殊指南	Following initial thaw, aliquot and freeze (-70°C).