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merck millipore,默克密理博,375240,HNF4 Antagonist, BI6015 - CAS 93987-29-2 - Calbiochem
产品名称：HNF4 Antagonist, BI6015 - CAS 93987-29-2 - Calbiochem
产品型号：375240
The HNF4 Antagonist, BI6, also referenced under CAS 93987-29-2, controls the biological activity of HNF4.
merck millipore,默克密理博,375240,HNF4 Antagonist, BI6015 - CAS 93987-29-2 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₁₅H₁₃N₃O₄S 93987-29-2 描述 概述 A cell-permeable phenylsulfonylbenzimidazole that is shown to dock in the ligand-binding pocket of both HNF4α and HNF4γ and antagonize HNF4α DNA binding activity in HepG2 cells (by 93%; 10 µM overnight), effectively inhibiting HNF4α-dependent cellular activities (Effective conc. 1 to 5 µM). HNF4γ inhibition by BI6015 can also lead to decreased insulin promoter binding by transactivators E47 & PDX-1 in T6PNE cells (5 µM 48 h). Although BI6015 is found to exhibit cancer-selective cytotoxicity toward a panel of 58 human cancer cells and Hep3B-Luc (Effective conc. 1 to 10 µM), but not primary murine hepatocytes, it does cause hepatic steatosis both in vitro and in mice in vivo, limiting its use in animal studies. BI6015 also inhibits Human CYP450 2C19 and rat L-type calcium channel (by 94% and 83%, respectively, at 10 µM), but not PPARγ or a panel of 41 receptors/enzymes of human, mouse, and rat origin. 产品目录编号 375240 品牌系列 Calbiochem®
同义词 Hepatocyte Nuclear Factor4 Antagonist, 2-Methyl-1-(2-methyl-5-nitrophenylsulfonyl)-1H-benzo[d]imidazole 参考 参考 Kiselyuk, A., et al. 2012. Chem. Biol. 19, 806. 产品信息 CAS号 93987-29-2 形式 Beige powder Hill配方 C₁₅H₁₃N₃O₄S Molar Mass 331.4 可逆 Y 结构配方图像 生物信息 主靶 HNFα & γ 纯度 ≥99% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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