merck millipore,默克密理愽
  • merck millipore,默克密理博,36-004,Anti-phospho-Bim EL (Ser65) Antibody

  • merck millipore,默克密理博,36-004,Anti-phospho-Bim EL (Ser65) Antibody

    产品名称：Anti-phospho-Bim EL (Ser65) Antibody
    产品型号：36-004
    This Anti-phospho-Bim EL (Ser65) Antibody is validated for use in IP, WB for the detection of phospho-Bim EL (Ser65).

    merck millipore,默克密理博,36-004,Anti-phospho-Bim EL (Ser65) Antibody

  • 产品介绍
  • merck millipore,默克密理博,36-004,Anti-phospho-Bim EL (Ser65) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MWBRbPurifiedPolyclonal Antibody
    描述
    产品目录编号 36-004
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-phospho-Bim EL (Ser65) Antibody
    产品信息
    格式 Purified
    控制
    • Bim protein phosphorylated by active JNK1a1/SAPK11c
    演示 Protein A Purified rabbit IgG in a solution of 0.1M Tris Glycine, 0.15M NaCl, 0.05% Sodium Azide, pH 7.4.
    应用
    应用 This Anti-phospho-Bim EL (Ser65) Antibody is validated for use in IP, WB for the detection of phospho-Bim EL (Ser65).
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 Peptide corresponding to amino acids 63-71 of human phospho-Bim EL (Ser65).
    宿主 Rabbit
    特异性 Recognizes phospho-Bim EL (Ser65).
    同种型 IgG
    品种反应性 RatHumanMouse
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_207002.2
    • NM_138622.2
    • NM_138623.2
    • NM_138624.2
    • NM_138626.2
    • NM_138627.2
    • NM_207003.1
    • NM_006538.3
    • NM_138621.3
    Entrez基因汇总 The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified.
    基因符号
    • BIM-alpha6
    • BCL2L11
    • BimL
    • BIM
    • BIM-beta7
    • BOD
    • BAM
    • BimEL
    • BIM-beta6
    修改
    • Phosphorylation
    纯化方法 Protein A purfied
    UniProt编号
    • O43521
    UniProt汇总 FUNCTION: SwissProt: O43521 # Induces apoptosis. Isoform BimL is more potent than isoform BimEL.
    SIZE: 198 amino acids; 22171 Da
    SUBUNIT: Forms heterodimers with a number of antiapoptotic Bcl-2 proteins including Mcl-1, Bcl-2, Bcl-X(L), BFL-1, and BHRF1. Does not heterodimerize with proapoptotic proteins such as BAD, BOK, BAX or BAK (By similarity).
    SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein. Note=Associated with intracytoplasmic membranes (By similarity).
    DOMAIN: SwissProt: O43521 The BH3 motif is required for Bcl-2 binding and cytotoxicity.
    SIMILARITY:
    产品使用声明
    质量保证 Routinely evaluated by immunoblot on phosphorylated Bim-GST.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 200 µg

    merck millipore,默克密理博,36-004,Anti-phospho-Bim EL (Ser65) Antibody

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