merck millipore,默克密理博,208925,Camptothecin, Camptotheca acuminata - CAS 2114454

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merck millipore,默克密理博,208925,Camptothecin, Camptotheca acuminata - CAS 2114454 - Calbiochem
产品名称：Camptothecin, Camptotheca acuminata - CAS 2114454 - Calbiochem
产品型号：208925
A cell-permeable DNA topoisomerase I inhibitor.

merck millipore,默克密理博,208925,Camptothecin, Camptotheca acuminata - CAS 2114454 - Calbiochem

产品介绍

merck millipore,默克密理博,208925,Camptothecin, Camptotheca acuminata - CAS 2114454 - Calbiochem

重要规格表

经验配方	CAS号
C₂₀H₁₆N₂O₄	7689-03-4

描述
概述	A cell-permeable DNA topoisomerase I inhibitor. Exhibits anti-leukemic and antitumor properties. Induces apoptosis in HL-60 cells and mouse thymocytes. Arrests cells at the G₂/M phase.
产品目录编号	208925
品牌系列	Calbiochem®
同义词	4-Ethyl-4-hydroxy-1H-pyrano[3ʹ,4ʹ:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)dione

参考
参考	Jones, C.B., et al. 1997. Cancer Chemother. Pharmacol. 40, 475. Staron, K., et al. 1994. Carcinogenesis 15, 2953. Tanizawa, A., et al. 1994. J. Natl. Cancer Inst. 86, 836. Gorczyca, W., et al. 1993. Toxicol. Lett. 67, 249. Onishi, Y., et al. 1993. Biochim. Biophys. Acta 1175, 147. Pantazis, P., et al. 1993. Int. J. Cancer 53, 863. Morham, S.G., and Shuman, S. 1992. J. Biol. Chem. 267, 15984. Hertzberg, R.P., et al. 1990. Biochem. J. 28, 4629. Hertzberg, R.P., et al. 1990. J. Biol. Chem. 265, 19287. Hsiang, Y.H., et al. 1985. J. Biol. Chem. 260, 14873.

参考

Jones, C.B., et al. 1997. Cancer Chemother. Pharmacol. 40, 475.
Staron, K., et al. 1994. Carcinogenesis 15, 2953.
Tanizawa, A., et al. 1994. J. Natl. Cancer Inst. 86, 836.
Gorczyca, W., et al. 1993. Toxicol. Lett. 67, 249.
Onishi, Y., et al. 1993. Biochim. Biophys. Acta 1175, 147.
Pantazis, P., et al. 1993. Int. J. Cancer 53, 863.
Morham, S.G., and Shuman, S. 1992. J. Biol. Chem. 267, 15984.
Hertzberg, R.P., et al. 1990. Biochem. J. 28, 4629.
Hertzberg, R.P., et al. 1990. J. Biol. Chem. 265, 19287.
Hsiang, Y.H., et al. 1985. J. Biol. Chem. 260, 14873.

产品信息
CAS号	7689-03-4
具有ATP竞争性	N
形式	Pale yellow solid
Hill配方	C₂₀H₁₆N₂O₄
化学配方	C₂₀H₁₆N₂O₄
Molar Mass	348.4
可逆	N
结构配方图像

生物信息
主靶	DNA topoisomerase 1
纯度	≥95% by HPLC

理化信息
细胞可渗透	Y
溶解度	DMSO or MeOH

GHS安全信息
RTECS	UQ0492000

安全信息
R相	R: 25-36/37/38-46 Toxic if swallowed. Irritating to eyes, respiratory system and skin. May cause heritable genetic damage.
S相	S: 22-26-36/37/39-45 Do not breathe dust. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Toxic & Carcinogenic / Teratogenic
有害材料注意事项：	Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
储存	+2°C to +8°C
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.