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经验配方 C₂₁H₂₇N₃O₃S₂ 描述 概述 A highly potent and selective CAAX peptidomimetic of the carboxyl terminal of Ras proteins that inhibits farnesyl transferase (FTase) in vitro (IC50 = 500 pM). Inhibits geranylgeranyltransferase I (GGTase I) at much higher concentration (IC50 = 50 nM). Has been shown to selectively block the growth of a human lung carcinoma expressing oncogenic K-Ras in nude mice. Also inhibits oncogenic signaling and tumor growth of NIH 3T3 cells transformed with the Ras oncogene at 20 µM. 产品目录编号 344550 品牌系列 Calbiochem®
同义词 N-[2-phenyl-4-N[2(R)-amino-3-mercaptopropylamino benzoyl]-methionine, TFA 参考 参考 Lantry, L.E., et al. 2000. Carcinogenesis 21, 113.
Lerner, E.C., et al. 1995. J. Biol. Chem. 270, 26802.
Sun, J., et al. 1995. Cancer Res. 55, 4243.产品信息 具有ATP竞争性 N 形式 White solid 配方 Supplied as a trifluoroacetate salt. Hill配方 C₂₁H₂₇N₃O₃S₂ 化学配方 C₂₁H₂₇N₃O₃S₂ Molar Mass 433.6 吸湿 Hygroscopic
可逆 N 结构配方图像 生物信息 主靶 FTase in vitro 主靶IC50 500 pM against FTase in vitro 纯度 ≥90% by HPLC 理化信息 细胞可渗透 N 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 -20°C
吸湿 Hygroscopic
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 1 week at -70°C. 包装信息 惰性气体下包装 Packaged under inert gas
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