merck millipore,默克密理愽
  • merck millipore,默克密理博,341609,FGF Receptor Tyrosine Kinase Inhibitor IV, NP603 - CAS 949164-80-1 - Calbiochem

  • merck millipore,默克密理博,341609,FGF Receptor Tyrosine Kinase Inhibitor IV, NP603 - CAS 949164-80-1 - Calbiochem

    产品名称：FGF Receptor Tyrosine Kinase Inhibitor IV, NP603 - CAS 949164-80-1 - Calbiochem
    产品型号：341609
    The FGF Receptor Tyrosine Kinase Inhibitor IV, NP603 controls the biological activity of FGF Receptor Tyrosine KInase. Primarily used for Phosphorylation & Dephosphorylation applications.

    merck millipore,默克密理博,341609,FGF Receptor Tyrosine Kinase Inhibitor IV, NP603 - CAS 949164-80-1 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,341609,FGF Receptor Tyrosine Kinase Inhibitor IV, NP603 - CAS 949164-80-1 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₆H₂₆N₂O₅949164-80-1
    描述
    概述 A cell-permeable SU6668 (PDGFR Tyrosine Kinase Inhibitor VI, Cat. No. 521235) derivative that targets the ATP-binding pocket and inhibits the kinase activity of FGFR1, PDGFRβ, and VEGFR2 (IC50 = 520, 780, and 930 nM, respectively), while exhibiting little activity against EGFR (IC50 >100 µM). Shown to exhibit anti-angiogenesis activity and suppress FGF-2-induced proliferation (IC50 = 18.2 µM) in HUVEC cultures in a dose-dependent manner.
    产品目录编号 341609
    品牌系列 Calbiochem®
    同义词 (Z)-3-(5-(6-(3,5-Dimethoxyphenyl)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-2,4-dimethyl-1H-pyrrol-3-yl)-propionic acid, NP603, VEGFR Tyrosine Kinase Inhibitor XXIX, VEGFR2 Kinase Inhibitor XXVII, PDGFR Tyrosine Kinase Inhibitor XVI
    参考
    参考 Kammasud, N., et al. 2009. Bioorg. Med. Chem. Lett. 19, 745.
    Kammasud, N., et al. 2007. Bioorg. Med. Chem. Lett. 17, 4812.
    产品信息
    CAS号 949164-80-1
    形式 Orange solid
    Hill配方 C₂₆H₂₆N₂O₅
    化学配方 C₂₆H₂₆N₂O₅
    Molar Mass 446.5
    结构配方图像
    生物信息
    纯度 ≥97% by HPLC
    理化信息
    溶解度 DMSO
    安全信息
    R相 R: 22-36/37/38

    Harmful if swallowed.
    Irritating to eyes, respiratory system and skin.
    S相 S: 26-36-45

    In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
    Wear suitable protective clothing.
    In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Harmful
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,341609,FGF Receptor Tyrosine Kinase Inhibitor IV, NP603 - CAS 949164-80-1 - Calbiochem

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