merck millipore,默克密理愽
  • merck millipore,默克密理博,341607,FGF/VEGF Receptor Tyrosine Kinase Inhibitor, PD173074 - CAS 219580-11-7 - Calbiochem

  • merck millipore,默克密理博,341607,FGF/VEGF Receptor Tyrosine Kinase Inhibitor, PD173074 - CAS 219580-11-7 - Calbiochem

    产品名称：FGF/VEGF Receptor Tyrosine Kinase Inhibitor, PD173074 - CAS 219580-11-7 - Calbiochem
    产品型号：341607
    The FGF/VEGF Receptor Tyrosine Kinase Inhibitor, PD173074 controls the biological activity of FGF/VEGF Receptor Tyrosine Kinase. Primarily used for Phosphorylation & Dephosphorylation applications.

    merck millipore,默克密理博,341607,FGF/VEGF Receptor Tyrosine Kinase Inhibitor, PD173074 - CAS 219580-11-7 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,341607,FGF/VEGF Receptor Tyrosine Kinase Inhibitor, PD173074 - CAS 219580-11-7 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₈H₄₁N₇O₃219580-11-7
    描述
    概述 A cell-permeable pyridopyrimidine compound that acts as a potent, ATP-competitive, and reversible inhibitor of FGF and VEGF receptors (IC50 = 21.5 nM for FGFR1). It inhibits PDGFR and c-Src only at much higher concentration (IC50 = 17.6 µM, 19.8 µM, respectively) and exhibits little effect against EGFR, InsR, MEK, and cPKC even at concentrations as high as 50 µM. Shown to inhibit the autophosphorylation of endogenous FGFR1 (IC50 <5 nM) and overexpressed VEGFR2 (IC50 <200 nM) in NIH3T3 cells in vitro, and FGF- and VEGF-induced angiogenesis in mice in vivo.
    产品目录编号 341607
    品牌系列 Calbiochem®
    同义词 1-t-Butyl-3-(6-(3,5-dimethoxyphenyl)-2-(4-diethylaminobutylamino)-pyrido[2,3-d]pyrimidin-7-yl)urea, PD173074, VEGFR Tyrosine Kinase Inhibitor XXIII, VEGFR2 Kinase Inhibitor XX
    参考
    参考 Koziczak, M., et al. 2004. Oncogene 23, 3501.
    Trudel, S., et al. 2004. Blood 103, 3521.
    Skaper, S.D., et al. 2000. J. Neurochem. 75, 1520.
    Mohammadi, M., et al. 1998. EMBO J. 17, 5896.
    产品信息
    CAS号 219580-11-7
    形式 Yellow solid
    Hill配方 C₂₈H₄₁N₇O₃
    化学配方 C₂₈H₄₁N₇O₃
    Molar Mass 523.7
    结构配方图像
    生物信息
    纯度 ≥97% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Irritant
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,341607,FGF/VEGF Receptor Tyrosine Kinase Inhibitor, PD173074 - CAS 219580-11-7 - Calbiochem

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